Neuroscience 2001 Abstract
| Presentation Number: | 870.10 |
|---|---|
| Abstract Title: | SUGGESTION OF MEDIAN NERVE MICROTRAUMA IN A RAT MODEL OF WORK-RELATED MUSCULOSKELETAL DISORDER. |
| Authors: |
Barbe, M. F.*1
; Barr, A. E.1
; Clark, B. D.1
; Al-Shatti, T. A.1
1Dept Physical Therapy, Temple Univ, Philadelphia, PA |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Trauma -- Nerve |
| Secondary Theme and Topics | Neurological and Psychiatric Conditions<br />- Neuromuscular Diseases |
| Session: |
870. Trauma: peripheral nerve injury Poster |
| Presentation Time: | Wednesday, November 14, 2001 2:00 PM-3:00 PM |
| Location: | Exhibit Hall YY-10 |
| Keywords: | nerve injury, macrophage, NT-3, Schwann Cell |
Work-related musculoskeletal disorder includes neuromusculoskeletal disorders that arise from repetitive tasks. These disorders may result from incomplete repair of tissue microtrauma induced by repeated submaximal levels of exertion. We have previously shown in a rat model that a high-repetition, negligible-force reaching and grasping task increases indicators of inflammation in both tendomuscular tissues and CNS (Barbe et al, SFN, 26(2), 2000). In this study, we examined anatomical and physiological changes in the median nerve in 19 Sprague-Dawley rats that had performed the task for 3 to 10 weeks. Median nerves within the carpal tunnel region were examined either immunocytochemically using antibodies against ED1, neutrophin 3 (NT3) and S100B, or neurophysiologically using a cuff electrode to record nerve conduction velocity (NCV). NT3 expression increased in Schwann cells (S100B-positive) within the median nerve of the reach limb by 6 weeks. All animals showed consistent, significant increases of ED1-expressing macrophages in the reach limb by 8 weeks. In contrast, NCV results were suggestive but not significant at 10 weeks. NCV in the reach limb of two of the four tested rats fell within the low portion of the range of control velocities. The third was extremely close to the mean of the controls. NCV could not be measured in the fourth due to a large neurofibroma in the vicinity of the carpal tunnel. Our results show that a highly repetitive task leads to histological signs of neurotrauma without clear-cut physiological changes. Supported by NIAMS AR 46426-02 and NIOSH OH 03970-01.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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