Neuroscience 2001 Abstract
| Presentation Number: | 866.7 |
|---|---|
| Abstract Title: | Chronic brain inflammation results in progressive MRI change and dementia in ischemic neurodegeneration. |
| Authors: |
Fujioka, M.*1
; Taoka, T.1
; Matsuo , Y.1
; Mishima, K.1
; Fujiwara, M.1
; Ogoshi, K.1
; Kondo, Y.1
; Sakaki, T.1
; Park , D.1
; Siesjo, B. K.1
1Neurosurgery, Nara Medical University, Nara, Japan |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Ischemia -- Cellular and molecular mechanisms |
| Secondary Theme and Topics | Cognition and Behavior<br />- Animal Cognition and Behavior<br />-- Attention |
| Session: |
866. Ischemia: cellular and molecular mechanisms XIII Poster |
| Presentation Time: | Wednesday, November 14, 2001 3:00 PM-4:00 PM |
| Location: | Exhibit Hall XX-21 |
| Keywords: | MCAO, oxidative stress, glia, behavior |
Brief ischemia leading to selective neuronal death and gliosis induces delayed T1 hyperintensity on MRI in the striatum of humans and rats (Stroke. 1999; 30: 1038-46). The MRI variation may stem from biochemical alterations including Mn-SOD induction in reactive glial cells. To clarify the significance of the MRI modification, we investigated the changes in the striatum of male wistar rats from 4 hours to 4 months after 15-min MCAO with regard to MRI, Mn concentration, neuronal number, immunoreactivities of astrocyte, microglia and Mn-SOD. The behavior study was performed to reveal brain function alteration in relation to the MRI and histological changes. We observed an increase in the T1 signal intensity of the lateral striatum 1 week after ischemia that subsequently decreased from 4 weeks and returned to baseline levels at 16 weeks. Mn-SOD immunoreactivity of glial cells in the lateral striatum increased from the 1st to the 3rd week and decreased from the 4th week after ischemia. The Mn concentration increased at the 14th day in the ischemic striatum compared to the non-ischemic contralateral striatum. The neuronal number in the lateral striatum continued to decrease up to 4 months after ischemia. The astrocytes and microglia, which proliferated within 4 hours after ischemia, continued to be activated 4 months later. The choice reaction time analysis showed the progressive deterioration of brain function. Our study suggests that chronic brain inflammation produces delayed ischemic MRI change which signifies striatal neurodegeneration and late-onset dementia.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
Copyright © 2001-2026 Society for Neuroscience; all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
