Neuroscience 2001 Abstract
| Presentation Number: | 866.2 |
|---|---|
| Abstract Title: | FUNCTIONAL RECOVERY OF REVERSIBLE CEREBRAL ISCHEMIA WITH PERFUSION AND DIFFUSION WEIGHTED MRI. |
| Authors: |
kim, J. H.*1,4
; lee, S.2,4
; hong, J. S.1
; kim, D. I.2,4
; Kim, C.3
; lee, J. E.1,4
1anatomy, Yonsei Univ Col Med, Seoul, Democratic People's Republic of Korea 2Diagnostic Radiology & Research Institute of Radiological Science, Yonsei Univ Col Med, Seoul, Democratic People's Republic of Korea 3anatomy, Korea Univ Col Med, Seoul, Democratic People's Republic of Korea 4BK21 Project for Medical Science,Yonsei, Seoul, Democratic People's Republic of Korea |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Ischemia -- Cellular and molecular mechanisms |
| Session: |
866. Ischemia: cellular and molecular mechanisms XIII Poster |
| Presentation Time: | Wednesday, November 14, 2001 2:00 PM-3:00 PM |
| Location: | Exhibit Hall XX-21 |
| Keywords: | CEREBRAL BLOOD FLOW, BRAIN IMAGING, MCAO, APOPTOSIS |
To evaluate the histological finding of reversible cerebral ischemic tissue on perfusion and diffusion weighted MRI, we produced the animal models of reversible cerebral ischemia in 10 cats by means of MCA occlusion with transorbital approach for an hour. MRI was performed at 1,3,6,24 and 36 hrs after reperfusion. Perfusion (PWI) and diffusion (DWI) weighted images were obtained. We divided the ischemic zones into the reversible and irreversible DWI zone. PWI revealed increased rCBV in all regions of the affected hemisphere on initial few hours. On initial DWI, increased signal intensity lesions were seen at ipsilateral striatum, superior/inferior temporal gyri and some parts of inferior frontal gyrus. In 6 cats, ADC recovery was noted at superior temporal and inferior frontal gyri, which also showed increased rCBV until the last PWI while striatum showed depletion of rCBV. Tissue slices were obtained after the last MRI. TUNEL stain and DNA ladder analysis were performed. We investigated differences in the degree of apoptosis between two zones on DWI. DWI reversible area showed positive TUNEL stain with lesser degree than the infarct area at striatum and inferior temporal gyri. Temporal cerebral ischemia induces reperfusion hyperemia and various degrees of programmed cell death even in the reversible zones on DWI although the extent of apoptosis is smaller than the infarct core. Reperfusion hyperemia can be one of the causes of programmed cell death in recovered cerebral tissue from ischemia.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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