Neuroscience 2000 Abstract
| Presentation Number: | 860.13 |
|---|---|
| Abstract Title: | The effect of amphetamine on brain lesion in rats evaluated by behaviour and MR imaging. |
| Authors: |
Lai, L. J.*1
; Abo, M.1
; Chen, Z.1
; Brown, A. I.2
; Bjelke, B.1
1MR-Center, Karolinska Institute, Stockholm, Sweden 2Dept. of Physical Medicine and Rehabilitation , Mayo Clinic, Rochester, MN |
| Primary Theme and Topics |
J. Disorders of the Nervous System and Aging - 136. Ischemia: functional outcome |
| Secondary Theme and Topics | H. Other Systems of the CNS<br />- 101. Brain metabolism and blood flow |
| Session: |
860. Ischemia: functional outcome I Poster |
| Presentation Time: | Thursday, November 9, 2000 8:00 AM-9:00 AM |
| Location: | Hall G-J |
| Keywords: | ISCHEMIA, HINDLIMB, MOTOR CORTEX, NEUROPATHOLOGY |
d-Amphetamine has been proposed to improve the recovery rate of beam walking ability after traumatic or ablation lesions in the sensori-motor cortex. The aim of this study is to investigate how postacute amphetamine treatment effect the recovery after a stroke like brain lesion. Male Sprague Dawley rats weighing 200 to 240 g were used in the study. A focal pan-necrotic lesion was made in the sensori-motor cortex using a photochemical lesion technique. Sensori-motor recovery was recorded daily for 14 days using beam walking as a behaviour test and a non parametric rating scale (1= unable, 7 = normal). A single dose d-amphetamine was administered i.p. 24 h after the lesion using the following doses and groups, 0.5 (n=8), 2.0 (n=8), 5.0 mg/kg (n=6) respectively, and saline as the control group (n=10). Magnetic resonance imaging (MRI) was performed 48 h after the lesion using a Biospec Avance 4.7T scanner. T2- Proton density- (PD) and apparent diffusion coefficient (ADC)-maps were calculated and evaluated. Using Kruskal-Wallis ANOVA followed by Mann-Whitney U as a and post-hoc test, no significant improvement was found in the beam walking performance after d-amphetamine treatment. The ADC values calculated from the core and periphery area of lesion was not significant different between the groups respectively. The size of the area showing an increased signal intensity on T2-weighted imaging did not show any significant difference between the control group and d-amphetamine-treated groups. Thus, these results indicate that there is no evidence for a beneficial effect from post acute d-amphetamine treatment in the late phase of stroke. Acknowledgements: Trygg Hansas Forskningsstiftelse, David och Astrid Hageléns stiftelse, Stroke-Förbundets Stiftelser och Fonder.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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