Neuroscience 2002 Abstract
| Presentation Number: | 889.16 |
|---|---|
| Abstract Title: | MRI DETECTED CINGULATE GYRUS AND CORTEX ATROPHY DURING AGING. |
| Authors: |
Bulgakova, M.*1
; Medina, D.2
; Stoub, T. R.2
; Wilson, R. S.2,3
; Bennet, D. A.2,3
; deToledo-Morrell, L.2
1Division of Neurobiology, Barrow Neurological Institute, Phoenix, AZ 2Neurological Sciences, Rush Universiy, Chicago, IL 3Rush Alzheimer's Disease Center, Rush University, Chicago, IL |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Aging -- Other |
| Session: |
889. Aging: other Poster |
| Presentation Time: | Thursday, November 7, 2002 11:00 AM-12:00 PM |
| Location: | Hall A2-B3 W-3 |
| Keywords: | IMAGING, LIMBIC SYSTEM |
The cingulate gyrus, a brain area important for certain cognitive functions, is pathologically involved in the very early stages of Alzheimer’s disease. In this study we investigated the extent of change in this region as a function of healthy aging. Participants consisted of: 1) 41 elderly individuals with normal cognition (mean age: 79.1, range: 67-89); and 2) 27 young adults (mean age: 28.1, range: 22-35). They all underwent a high resolution MRI scan. The cingulate gyrus was segmented from 1.6 mm gapless T1 weighted images using the protocol described by Killiany et al. (Ann Neurol., 2000). For each hemisphere, the volumes of the cingulate gyrus and cortex were derived separately. To correct for individual differences in brain size, the volumes of regions of interest were divided by total intracranial volume. The young participants differed significantly from the old in normalized total (right+left) cingulate gyrus (p<0.001) and cortex (p<0.001) volumes. Further analyses indicated that these age-related differences were evident for volumes of the posterior (p<0.001 for both gyrus and cortex), but not the caudal anterior cingulate. Thus, alterations in the anatomy of this region seem to start during healthy aging.
Supported by AG09466, AG10161 & AG17917
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
Copyright © 2002-2025 Society for Neuroscience; all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
