Neuroscience 2001 Abstract
| Presentation Number: | 86.5 |
|---|---|
| Abstract Title: | VOLUMETRIC AND HISTOPATHOLOGICAL CHANGES IN THE AGED RHESUS BRAIN. |
| Authors: |
Kohama, S. G.*1
; Kaye, J.2
; Shelton, S. E.3
; Kemnitz, J.4
; Uno, H.4
1Neuroscience, Oregon Regional Primate Research Center, Beaverton, OR 2Neurology, Oregon Health Sciences University, Portland, OR 3Psychiatry, University of Wisconsin, Madison, WI 4Wisconsin Regional Primate Research Center, Madison, WI |
| Primary Theme and Topics |
Cognition and Behavior - Animal Cognition and Behavior -- Cognitive learning and memory systems |
| Secondary Theme and Topics | Neurological and Psychiatric Conditions<br />- Aging<br />-- Other |
| Session: |
86. Animal cognition and behavior: cognitive learning and memory systems--aging and environmental enrichment Poster |
| Presentation Time: | Sunday, November 11, 2001 8:00 AM-9:00 AM |
| Location: | Exhibit Hall UU-8 |
| Keywords: | MACAQUE, CSF, IMAGING, GLIA |
The rhesus monkey brain undergoes age-related changes after 25 years of age, such as the appearance of amyloid plaques. However, the effect of age on brain volume is more controversial, especially in light of reports of stability of brain weight and neuron number. To address this issue 27 animals (7-37 years old) were examined by magnetic resonance imaging (MRI) between the Oregon and Wisconsin Regional Primate Research Centers. With numerical emphasis on older animals (18 of the 27 were 25 years of age or older), brains were imaged using multi-echo and 3D-SPGR protocols on 1.5 Tesla Signa scanners. Image analysis revealed a progressive age-related increase in cerebrospinal fluid, with a concomitant decrease in brain volume in monkeys after 25 years of age. This was visualized as a dilation of ventricular space throughout the brains and measured in a subset of animals. In addition, T2-weighed MRI scans revealed a progressive decrease in signal intensity over a larger volume in the globus pallidus and substantia nigra, suggesting increased levels of iron. The latter was further examined histologically in an additional group of 33 animals (6-32 years old). Iron-positive pigments were seen in scattered glial cells in neural and perivascular spaces in these brain regions. In sum, general age-related changes in brain structure were found to occur in rhesus monkeys at two different geographical sites, suggesting that common functional consequences will also be present in these different populations.
Supported by RR 00163, RR 00167 AND AG08017
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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