Neuroscience 2002 Abstract
| Presentation Number: | 889.2 |
|---|---|
| Abstract Title: | SPECIFIC AGE-RELATED WHITE MATTER CHANGES IN THE RHESUS MONKEY BRAIN USING DT-MRI. |
| Authors: |
Makris, N.*1
; van der Kouwe, A.2
; Normandin, J. J.1
; Dale, B.2
; Wald, L.2
; Killiany, R. J.3
; Moore, T. L.3
; Papadimitriou, G. M.1
; McInerney, S.1
; Sanders, H. A.1
; Kennedy, D. N.1
; Moss, M. B.3
; Caviness, Jr., V. S.1
; Rosene, D. L.3
1Neurology, Massachusetts General Hospital, Boston, MA 2Radiology, Massachusetts General Hospital, Boston, MA 3Anatomy and Neurobiology, Boston University Medical School, Boston, MA |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Aging -- Other |
| Secondary Theme and Topics | Cognition and Behavior<br />- Animal Cognition and Behavior<br />-- Cognitive learning and memory systems |
| Session: |
889. Aging: other Poster |
| Presentation Time: | Thursday, November 7, 2002 9:00 AM-10:00 AM |
| Location: | Hall A2-B3 W-3 |
| Keywords: | MACAQUE, MRI, CONNECTION, BRAIN |
Rhesus monkeys undergo cognitive decline as a function of age, which correlates with the breakdown of axonal myelin. Whether the myelin breakdown is diffuse or specific to individual white matter fiber pathways remains to be clarified. In the present study we investigated the changes in the cingulum bundle using DT-MRI in young (Group 1, N=5), middle-aged (Group 2, N=2), and old (Group 3, N=6) monkeys. METHOD: MRI scanning was performed using a Siemens Sonata 1.5T. Scans included sagittal MP-RAGE pulse sequences and echo-planar DT-MRI. The diffusion tensor, D, was sampled using a seven-shot EPI technique with the following parameters: TR=130ms, TE=80ms, 96 averages, voxel size=1.3x1.3x2.0mm3, b=600s/mm2, 40 contiguous coronal slices for a total acquisition time=66 minutes and SNR=100. RESULTS: The average total cingulum bundle volumes were 0.60cm3 (SD=0.19) in Group 1, 0.75cm3 (SD=0.19) in Group 2, and 0.49cm3 (SD=0.28) in Group 3. The average total cingulum bundle fractional anisotropy (FA) values were 0.43 (SD=0.11) in Group 1, 0.51 (SD=0.07) in Group 2, and 0.39 (SD=0.11) in Group 3. The average total cingulum bundle lattice anisotropy (LA) values were 0.29 (SD=0.11) in Group 1, 0.37 (SD=0.09) in Group 2, and 0.25 (SD=0.10) in Group 3. The observed changes in size and anisotropy suggest that the cingulum bundle could well be an important structure associated with age-related cognitive decline in the rhesus monkey.
Supported by NARSAD, and ALSA
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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