Neuroscience 2005 Abstract
| Presentation Number: | 798.10 |
|---|---|
| Abstract Title: | A <sup>31</sup>P-<sup>1</sup>H MRS and MRI study of metabolic effects of chronic alcoholism. |
| Authors: |
McClure, R. J.*1
; Pettegrew, J. W.1
; Goldstein, G.1,2
; Panchalingam, K.1
; Mandal, P. K.1
; Calhoun, V. C.3
; Pearlson, G. D.3
1Neurophysics Lab., Dept. Psychiatry, Univ. of Pittsburgh, Pittsburgh, PA 2PA, 130 DeSoto St, 15213, 3USA, 130 DeSoto St, 15213, |
| Primary Theme and Topics |
Disorders of the Nervous System - Addiction and Drugs of Abuse -- Alcohol |
| Session: |
798. Neurobiological Effects of Alcohol Consumption II Poster |
| Presentation Time: | Tuesday, November 15, 2005 2:00 PM-3:00 PM |
| Location: | Washington Convention Center - Hall A-C, Board # VV59 |
| Keywords: | PHOSPHOLIPID, COGNITION, IN VIVO, MEMBRANE |
Subjects with chronic alcoholism demonstrate cognitive performance ranging from normal to severely impaired. Some chronic alcoholism subjects have white matter volume reductions in prefrontal, posterior superior temporal, and posterior parietal-occipital regions and less prominent, diffuse grey matter volume reductions. We examined measures of membrane phospholipid and high-energy phosphate metabolism and neuronal integrity [NA(s-τc)] by 31P-1H magnetic resonance spectroscopic imaging in a cohort of chronic alcoholism subjects without cognitive changes (CUCAL) (5M, 48.2±3.7 yrs) and with cognitive impairment (CICAL) (4M, 49.5±4.0 yrs) compared with controls (16M, 40.8±5.9 yrs). Cognitive status was determined by an index from the Halstead-Reitan Battery. CUCAL subjects had increased levels of membrane phospholipid building blocks [PME(s-τc)] in the right (R) occipital cortex compared with controls. Compared with CUCAL subjects, CICAL subjects had: 1) increased measures of PME(s-τc) in R superior temporal and left (L) inferior parietal but decreases in R occipital regions; 2) decreased measures of synaptic vesicles [PDE(i-τc)] in the R inferior parietal lobe; 3) increased measures of lipid/protein glycosylation and membrane phospholipid cofactors [(α-γ)ATP] in the L occipital cortex and 4) increased measures of NA(s-τc) in L superior temporal, R basal ganglia, and R inferior parietal regions. These findings suggest CICAL subjects have increased neural membrane repair mechanisms which are failing [↑PME(s-τc), ↑(α-γ)ATP, ↑NA(s-τc)], consistent with evidence of loss of synaptic/transport vesicles [↓PDE(i-τc)]. In the R occipital cortex PME(s-τc) negatively correlated with grey matter in that voxel (r=-0.754, p=0.01). Thus reduction in grey matter in the R occiptial region correlated with increased membrane phospholipid precursors, likely reflecting attempts at membrane repair triggered by neural membrane degeneration.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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