Neuroscience 2002 Abstract
| Presentation Number: | 887.4 |
|---|---|
| Abstract Title: | Tau Gene Linkage Disequilibrium Analysis Implicates Region for Risk Variants in PD, PSP and CBD. |
| Authors: |
Skipper, L. M.*1
; Baker, M.1
; Wilkes, K.1
; Manning, J.1
; Bisceglio, G.1
; Hutton, M.1
; Aasly, J.2
; Farrer, M.1
1Department of Neurogenetics, Mayo Clinic, Jacksonville, FL 2Department of Neurology, University Hospital, Trondheim, Norway |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Neurodegenerative Disorders -- Parkinsons Disease: Other |
| Session: |
887. Neurodegenerative disorders: Parkinson's disease--other I Poster |
| Presentation Time: | Thursday, November 7, 2002 11:00 AM-12:00 PM |
| Location: | Hall A2-B3 U-25 |
| Keywords: | ASSOCIATION, PARKINSONISM, SINGLE NUCLEOTIDE POLYMORPHISM |
We have recently confirmed an association between the Tau H1 haplotype and clinically defined Parkinson’s Disease (PD) in the Norwegian population. In this further extended case-control series, we present systematic association and linkage disequilibrium analyses using Single Nucleotide Polymorphisms spanning the Tau gene. Strong disequilibrium in PD cases implicates an intragenic region likely to contain variants attributing to increased risk of PD, Progressive Supranuclear Palsy (PSP) and Corticobasal Degeneration (CBD).
Supported by M Farrer
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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