Neuroscience 2001 Abstract
| Presentation Number: | 858.16 |
|---|---|
| Abstract Title: | EFFECTS OF STRESS-INDUCED NOREPINEPHRINE RELEASE IN CENTRAL AMYGDALA ON ACTH SECRETION AND BEHAVIORAL REACTIVITY TO STRESS. |
| Authors: |
Cecchi, M.*1
; Khoshbouei, H.1
; Morilak, D. A.1
1Pharmacol, Univ Texas HSC San Antonio, San Antonio, TX |
| Primary Theme and Topics |
Cognition and Behavior - Behavioral Pharmacology -- Monoamines and behavior |
| Secondary Theme and Topics | Autonomic, Limbic and Other Systems<br />- Stress and the Brain<br />-- Stress-induced behaviors |
| Session: |
858. Behavioral pharmacology: monoamines and behavior IV Poster |
| Presentation Time: | Wednesday, November 14, 2001 4:00 PM-5:00 PM |
| Location: | Exhibit Hall VV-11 |
| Keywords: | Anxiety, HPA Axis, Elevated Plus Maze, Social Interaction Test |
The Central Amygdala (CeA) is a component of a limbic fear-anxiety circuit, and has also been implicated in modulating the hypothalamic-pituitary-adrenal (HPA) stress axis. CeA receives dense noradrenergic innervation, and norepinephrine (NE) release in CeA is elevated by immobilization stress (IMM) (Khoshbouei, SFN 2000). We hypothesized that NE release in CeA may modulate stress-induced anxiety-like behavioral responses and HPA activation. To examine the role of NE in the CeA on stress-induced behavioral responses, male Sprague-Dawley rats were tested on the Social Interaction (SI) and Elevated Plus-Maze (EPM) tests after bilateral microinjection of adrenergic antagonists into CeA (0.25 μl) immediately prior to 5 min IMM. In the SI test, the α1-antagonist benoxathian (2 nmole) blocked the anxiogenic effect of acute stress (p<0.05), while β-receptor blockade (betaxolol + ICI181555, 1 nmole each) had no effect. By contrast, neither α1 nor β antagonists blocked the anxiogenic effect of IMM on the EPM, suggesting that these two tests measure different aspects of behavioral stress reactivity. Likewise, neither α1 nor β antagonists in CeA altered IMM-induced ACTH secretion. These results contrast with previous findings in which adrenergic antagonists in the Lateral Bed Nucleus of the Stria Terminalis, a related part of the extended amygdala, attenuated both stress-induced HPA activation and anxiety-like behavioral responses on the EPM, but not the SI test (Cecchi, SFN 2000). Together, these data suggest that NE release in the limbic forebrain facilitates different components of the stress response in region- and context-specific ways.
Supported by NIMH grant MH53851
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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