Neuroscience 2005 Abstract
| Presentation Number: | 793.8 |
|---|---|
| Abstract Title: | Lithium effects on human brain structure mapped using longitudinal MRI. |
| Authors: |
Leow, A. D.*1
; Thompson, P. M.1
; Hayashi, K. M.1
; Bearden, C.2
; Nicoletti, M. A.3
; Monkul, S. E.4
; Brambilla, P.4
; Sassi, R. B.4
; Mallinger, A. G.4
; Soares, J. C.3
1Neurology, UCLA School of Medicine, Los Angeles, CA 2Psychiatry, UCLA School of Medicine, Los Angeles, CA 3TX, 710 Westwood Plaza, 90095, 4USA, 710 Westwood Plaza, 90095, |
| Primary Theme and Topics |
Disorders of the Nervous System - Cognitive, Emotional and Behavioral State Disorders -- Affective disorders: Experimental pharmacotherapeutics |
| Secondary Theme and Topics | Disorders of the Nervous System<br />- Cognitive, Emotional and Behavioral State Disorders<br />-- Affective disorders: Functional deficits |
| Session: |
793. Mood Stabilizers: Novel Mechanisms Poster |
| Presentation Time: | Tuesday, November 15, 2005 4:00 PM-5:00 PM |
| Location: | Washington Convention Center - Hall A-C, Board # UU75 |
| Keywords: | BIPOLAR, IMAGING, MEDICATION, ANATOMY |
Prior MRI studies have shown cortical gray matter increases in bipolar patients treated with lithium, but it is unknown whether this is related to the disease process. We studied serial structural MRI brain scans (3D SPGR, 1.5 mm slices) from 13 healthy subjects (6F/7M; mean age: 25.5 yrs.+/-10.0SD, scan interval: 4 weeks) treated with 0.5-1.5 mEq/L lithium (a therapeutic dose). To map 3D patterns of local tissue changes over time, an intensity-based elastic registration algorithm deformed the follow-up to the baseline scan by maximizing the mutual information. A tissue change map (the Jacobian of the deformation), for each individual, was nonlinearly normalized to the anatomical space of a reference subject. Mean lithium effects were established by voxel-wise averaging the log-transformed Jacobian maps. Significant tissue hypertrophy was detected. A 2-4% average volume increase was detected in primary sensorimotor and superior frontal regions, consistent with tissue gains localized in prior cortical mapping studies of medicated bipolar patients. A one-sample test on the 13 logged Jacobian maps, conducted voxelwise, gave a p-value of 0.039 after multiple comparisons correction. Brain structural change is therefore detectable in healthy subjects treated with lithium at therapeutic doses. These MRI changes may reflect neuropil increase, as lithium is known to increase levels of the neuroprotective protein B-cell lymphoma protein-2 (bcl-2) in the frontal cortex.
Supported by NIH/VA/CAPES (Brazil)
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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