Neuroscience 2000 Abstract
| Presentation Number: | 850.3 |
|---|---|
| Abstract Title: | Effect of THC on conditioned and unconditioned sickness behaviors elicited by lithium in <I>Suncus murinus</I> (house musk shrew). |
| Authors: |
Kemp, S. W. P.*1
; Parker, L. A.1
1Psychology, Wilfrid Laurier University, Waterloo, Canada |
| Primary Theme and Topics |
I. Neural Basis of Behavior - 115. Ingestive behaviors |
| Secondary Theme and Topics | I. Neural Basis of Behavior<br />- 109. Learning and memory: pharmacology |
| Session: |
850. Ingestive behaviors: taste aversion Poster |
| Presentation Time: | Thursday, November 9, 2000 10:00 AM-11:00 AM |
| Location: | Hall G-J |
| Keywords: | emesis, nausea, cannabinoids, Conditioning |
The effect of the cannabinoid, Δ9-THC, on conditioned and unconditioned sickness was evaluated in the Suncus murinus, an emetic species. Experiment 1 demonstrated that, at the doses tested, THC did not suppress unconditioned vomiting elicited by lithium chloride. In a drug-free test of conditioned sickness, Experiment 2 revealed that shrews displayed conditioned gaping (a precursor to vomiting) when subsequently exposed to the lithium-paired chamber. THC suppressed conditioned gaping. These results support anecdotal suggestions that THC may reduce conditioned nausea in humans.
Supported by NSERC (Grant OGP-92057) to LAP
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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