Neuroscience 2001 Abstract
| Presentation Number: | 855.3 |
|---|---|
| Abstract Title: | The Aging Great Ape Brain: A Volumetric MRI Study of Hippocampus and Striatum. |
| Authors: |
Erwin, J. M.*1,10
; Sherwood, C. C.2,9
; Delman, B. N.5
; Naidich, T. P.5
; Gentile, J. C.5
; Bruner, H. J.3
; Braun, A. R.8
; Holloway, R. L.2,9
; Gannon, P. J.6,9
; Perl, D. P.7,10
; Hof, P. R.4,9,10
1Bioqual, Rockville, MD 2Anthropology, Columbia U, NY, NY 3Phys & Surg, Columbia U, NY, NY 4Neurobiology, MSSM, NY, NY 5Radiology, MSSM, NY, NY 6Otolaryngology, MSSM, NY, NY 7Pathology, MSSM, NY, NY 8NIDCD, Bethesda, MD 9NYCEP, NY, NY 10FCCB, Blacksburg, VA |
| Primary Theme and Topics |
Cognition and Behavior - Neuroethology |
| Session: |
855. Neuroethology: comparative anatomy and brain evolution Poster |
| Presentation Time: | Wednesday, November 14, 2001 3:00 PM-4:00 PM |
| Location: | Exhibit Hall UU-21 |
| Keywords: | comparative anatomy, brain evolution |
Considering the close phylogenetic relationship between humans and chimpanzees, it is of particular interest to characterize the age-related changes of the chimpanzee brain that correspond to key foci of pathologic brain aging in humans such as hippocampus, entorhinal cortex, and basal ganglia. Recently, we reported that, unlike aged humans with neurodegenerative pathology, aged great apes have preserved neuron number and cellular volume in layer II neurons of the entorhinal cortex. In the present study, we measured the volume of the hippocampus, caudate nucleus, and putamen from magnetic resonance images (MRIs) of a cross-sectional age-graded sample of postmortem chimpanzee brains. Volumes of interest (VOIs) were measured from either axial T1 weighted or coronal T2 weighted scans, using MRIcro software. VOI measurements were normalized for whole brain volume. Whole brain, raw VOI, and normalized VOI volumes were not correlated with age. ANOVA found no differences in any VOI between age cohorts (19-27 and 37-44). These results suggest that the chimpanzee brain ages differently than either the normal or the demented human brain. Small samples of gorilla and orangutan brains similarly display minimal age-related reduction of striatum and hippocampus. These data suggest that morphologic correlates of age-related cognitive deficits in great apes are likely due to subtle cellular alterations in select neuronal populations.
Supported by Bioqual, FCCB, NYCEP, MSSM, NIH (AG14308), NSF, and the Leakey Foundation
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
Copyright © 2001-2025 Society for Neuroscience; all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
