Neuroscience 2000 Abstract
| Presentation Number: | 846.4 |
|---|---|
| Abstract Title: | Effects of THC and SR-141716 on timing behavior in rats. |
| Authors: |
Popke, E. J.*1
; Mayorga, A. J.1
; Fogle, C. M.1
; Paule, M. G.1
1Division of Neurotoxicology, National Center for Toxicological Research, FDA, Jefferson, AR |
| Primary Theme and Topics |
I. Neural Basis of Behavior - 111. Biological rhythms |
| Secondary Theme and Topics | D. Neurotransmitters, Modulators, Transporters, and Receptors<br />- 54. Cannabinoids |
| Session: |
846. Biological rhythms: pharmacology Poster |
| Presentation Time: | Thursday, November 9, 2000 11:00 AM-12:00 PM |
| Location: | Hall G-J |
| Keywords: | CANNABINOIDS |
The effects of marijuana and THC on time perception are well documented. Yet, little is known about the mechanisms that underlie these effects. The present series of experiments examined the effects of THC (0.01-5.0 mg/kg) and of the CB-1 antagonist SR-141716 (0.01-3.0 mg/kg) using a 10-14 second temporal response differentiation schedule in male Sprague-Dawley rats. Under this schedule, subjects were required to make a continuous response on an operant lever for at least 10, but not more than 14 seconds. Releasing the lever within this 10-14 second window resulted in food pellet delivery. Failure to release the lever within this 10-14 second window had no programmed consequences. Acute administration of SR-141716 shifted the distribution of response durations to the right, perhaps suggesting a slowing of the internal timer. In a separate experiment, acute administration of THC produced a generalized disruption in task performance but did not systematically alter the distribution of TRD response durations. Preliminary results of a third experiment suggest that THC pre-treatment can alter the effects of subsequently-administered SR-141716 on timing. This pattern of results suggest that the internal timing mechanisms may be under tonic control by an endogenous cannabinoid ligand and that this mechanism remains largely unaffected by additional exogenous stimulation.
Supported by : NCTR Protocol #6917
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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