Neuroscience 2001 Abstract
| Presentation Number: | 852.21 |
|---|---|
| Abstract Title: | MRI and PET template images for neuroimaging in baboon and macaque. |
| Authors: |
Snyder, A. Z.*2,3
; Black, K. J.1,2,3
; Koller, J. M.4
; Gado, M. H.3
; Perlmutter, J. S.2,3
1Psychiatry, Washington Univ, St Louis, MO 2Neurology, Washington Univ, St Louis, MO 3Radiology, Washington Univ, St Louis, MO 4School of Engineering, Washington Univ, St Louis, MO |
| Primary Theme and Topics |
Cognition and Behavior - Animal Cognition and Behavior -- Learning & memory: Physiology and imaging |
| Session: |
852. Animal cognition and behavior: learning and memory--physiology and imaging V Poster |
| Presentation Time: | Wednesday, November 14, 2001 1:00 PM-2:00 PM |
| Location: | Exhibit Hall TT-31 |
| Keywords: | Papio, Macaca nemestrina, fMRI, atlas |
Co-registering functional brain images across subjects offers experimental advantages and is widely used for studies in humans. Voxel-based co-registration methods require a high-quality 3D template image. Here we describe the formation of T1-weighted structural MRI and PET blood flow template images for baboon and Macaca nemestrina. The images derive from 9 baboons, 12 macaques, and over 500 PET [15O]water scans. Custom software aligns individual MR images to the MRI template using a 12-parameter (affine) model. In the realigned baboon MR images, subcortical test points correspond closely to a photomicrographic atlas with an average error of 1.53mm. Cortical test points on average were within 1.99mm of the mean location for each point. Alignment of individual PET blood flow images directly to the PET template was compared to a two-step alignment process via each subject's MR image. The two transformations were identical within 0.41 mm, 0.54 degrees, and 1.0 percent (translation, rotation, and linear stretch; mean), validating both the alignment software and the template images.
For macaque, we created template images in register with the baboon template to allow cross-species functional comparisons. Alignment of selected internal fiducial points was accurate to within 1.9mm (mean) across species. We also provide macaque template images in register with the UCLA online M. nemestrina atlas.
The baboon (purl.org/net/kbmd/b2k) and macaque (purl.org/net/kbmd/n2k) templates can be used as targets for any image registration method.
For macaque, we created template images in register with the baboon template to allow cross-species functional comparisons. Alignment of selected internal fiducial points was accurate to within 1.9mm (mean) across species. We also provide macaque template images in register with the UCLA online M. nemestrina atlas.
The baboon (purl.org/net/kbmd/b2k) and macaque (purl.org/net/kbmd/n2k) templates can be used as targets for any image registration method.
Supported by NINDS, NARSAD, TSA, APDA, Mary and Robert Bronstein Foundation, McDonnell Center for the Study of Higher Brain Function
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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