Neuroscience 2001 Abstract
| Presentation Number: | 845.9 |
|---|---|
| Abstract Title: | Working Memory in Obstructive Sleep Apnea: a Functional Magnetic Resonance Imaging Study. |
| Authors: |
Thomas, R. J.*1
; Rosen, B. R-.2
; Bush, G.2
; Kwong, K. K-.2
1Division of Pulmonary and Critical Care, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 2MGH-NMR Center, Massachusetts General Hospital, Boston, MA |
| Primary Theme and Topics |
Autonomic, Limbic and Other Systems - Biological Rhythms and Sleep |
| Secondary Theme and Topics | Cognition and Behavior<br />- Human Cognition and Behavior<br />-- Executive function: Working memory |
| Session: |
845. Biological rhythms and sleep XIII Poster |
| Presentation Time: | Wednesday, November 14, 2001 1:00 PM-2:00 PM |
| Location: | Exhibit Hall SS-8 |
| Keywords: | fMRI, OSA, verbal 2-back task, dorsolaeral prefrontal cortex dysfunction |
Introduction: Executive function abnormalities have been described in patients with obstructive sleep apnea (OSA). There is evidence that the prefrontal cortex may be vulnerable in states of disrupted sleep. We describe the results of a functional magnetic resonance imaging study (fMRI) of working memory in 11 patients with OSA.
Hypothesis: Impaired executive function in OSA patients is due to regional (dorsolateral prefrontal cortex, DLPFC) dysfunction in the prefrontal cortex.
Study design and methods: Prospective clinical and fMRI (Siemens 3T scanner) evaluation of patients with severe OSA. The task paradigm was two runs of a block design verbal 2-back task with each run lasting 13 minutes. 16 slices parallel to the AC-PC line were obtained every 2 seconds. Statistical activation maps were generated using the Brain Voyager software.
Results: 11 male patients, mean age 42. Prior to therapy with PAP, 11/11 patients demonstrated poor or absent prefrontal (including DLPFC) activation. Posterior parietal activation was seen in all patients, and anterior cingulate activation in 10. At the time of abstract preparation, 4 patients have been studied following a minimum of 6 weeks of optimal therapy. There was a recovery of prefrontal activation in 3/4 patients. Mean Epworth Sleepiness Score was 16 prior to therapy, and 4 post-therapy.
Conclusions: The demonstrated functional abnormality in activation during a working memory task is consistent with the known clinical abnormality in patients with OSA.
Hypothesis: Impaired executive function in OSA patients is due to regional (dorsolateral prefrontal cortex, DLPFC) dysfunction in the prefrontal cortex.
Study design and methods: Prospective clinical and fMRI (Siemens 3T scanner) evaluation of patients with severe OSA. The task paradigm was two runs of a block design verbal 2-back task with each run lasting 13 minutes. 16 slices parallel to the AC-PC line were obtained every 2 seconds. Statistical activation maps were generated using the Brain Voyager software.
Results: 11 male patients, mean age 42. Prior to therapy with PAP, 11/11 patients demonstrated poor or absent prefrontal (including DLPFC) activation. Posterior parietal activation was seen in all patients, and anterior cingulate activation in 10. At the time of abstract preparation, 4 patients have been studied following a minimum of 6 weeks of optimal therapy. There was a recovery of prefrontal activation in 3/4 patients. Mean Epworth Sleepiness Score was 16 prior to therapy, and 4 post-therapy.
Conclusions: The demonstrated functional abnormality in activation during a working memory task is consistent with the known clinical abnormality in patients with OSA.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
Copyright © 2001-2025 Society for Neuroscience; all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
