Neuroscience 2002 Abstract
| Presentation Number: | 872.7 |
|---|---|
| Abstract Title: | A META-ANALYSIS OF MRI-BASED VOLUMETRIC ASYMMETRY OF THE HIPPOCAMPUS AND AMYGDALA IN >1500 NORMAL ADULTS. |
| Authors: |
Pedraza, O.*1,3
; Bowers, D.1,2,3
; Gilmore, R.2,3
; Eisenschenk, S.2,3
1Clinical & Health Psychology, University of Florida, Gainesville, FL 2Neurology, University of Florida, Gainesville, FL 3McKnight Brain Institute, University of Florida, Gainesville, FL |
| Primary Theme and Topics |
Cognition and Behavior - Human Cognition and Behavior -- Learning and memory |
| Session: |
872. Human cognition and behavior: learning and memory XI Poster |
| Presentation Time: | Thursday, November 7, 2002 10:00 AM-11:00 AM |
| Location: | Hall A2-B3 N-19 |
| Keywords: | EPILEPSY, DEMENTIA, DEPRESSION, MEMORY |
Previous research in humans has explored the relationship between volumetric measurements of the hippocampus and amygdala, the degree of volumetric asymmetry of these structures, and various cognitive and psychiatric symptoms. The present study provides the first systematic analysis using meta-analytic procedures of the normal population parameters of hippocampal and amygdala volumetric asymmetry as well as absolute intrahemispheric volumes in healthy adult individuals. A literature review resulted in a representative sample of 62 studies (N = 2,364 participants) providing volumetric information for the left and right hippocampi and 38 studies (N = 1,569 participants) providing volumetric information for the left and right amygdala. Results revealed that, in humans, the hippocampus is a statistically reliable asymmetrical structure in normal adults, with a relative larger right hemisphere volume (effect size Dh = 0.19, p < 0.001). The amygdala, however, was not found to be reliably asymmetrical. Additional analyses suggested that differences in MRI magnet field strength and slice thickness values may differentially contribute to volumetric asymmetry estimates. These results expand on previous normative studies and may be relevant to clinical researchers studying the clinical correlates of hippocampal and amygdala volumes in patients with epilepsy, mild cognitive impairment, dementia, and various psychiatric disorders.
Supported by R01-MH62539
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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