Neuroscience 2000 Abstract
| Presentation Number: | 838.11 |
|---|---|
| Abstract Title: | Psychopharmacology of eye movements: case reports. |
| Authors: |
Larrison, A. L.*1
; Sereno, A. B.2
1Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ 2Dept. of Neurobiology and Anatomy, University of Texas-Houston Medical School, Houston, TX |
| Primary Theme and Topics |
I. Neural Basis of Behavior - 104. Cognition: attention |
| Secondary Theme and Topics | J. Disorders of the Nervous System and Aging<br />- 146. Drugs of abuse: opioids and others |
| Session: |
838. Cognition: attention IV Poster |
| Presentation Time: | Thursday, November 9, 2000 10:00 AM-11:00 AM |
| Location: | Hall G-J |
| Keywords: | Visual, Attention, Drug, Human |
Subjects tested in experiments while self-reporting concurrent use of centrally acting drugs are usually excluded from data analyses. We compiled data from such subjects and present them as individual case reports. Subjects taking fluoxetine, St. John's Wort, baclophen, dextroamphetamine, ketamine, marijuana, methadone, codeine, benzodiazepines and estrogen are reported. Very few subjects demonstrated notable differences on saccade, antisaccade or orienting tasks including facilitation and inhibition of return. However, subjects taking dextroamphetamine and ketamine showed marked changes in orienting, with both greater and prolonged facilitation to cued locations and delayed onset of inhibition of return. Baclophen was associated with pronounced increases in anti-saccade errors. Subjects taking large doses of methadone or codeine demonstrated no impairments on the saccade or antisaccade task, however, a non-medicated recovering heroin addict showed marked impairments in fixation stability and antisaccade performance. We will discuss how these studies may indicate important areas of further investigation with respect to understanding the effects of pharmacological agents on eye movements and attention.
Supported by McDonnell-Pew and NARSAD
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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