Neuroscience 2001 Abstract
| Presentation Number: | 83.15 |
|---|---|
| Abstract Title: | Diffusion MRI tracking of amygdalo-calcarine pathways: replication and detailed error study. |
| Authors: |
Lori, N. F.*1
; Akbudak, E.1
; Shimony, J. S.1
; Snyder, A. Z.1
; Burton, H.1
; Raichle, M. E.1
; Price, J. L.1
; Conturo, T. E.1
1Dept. of Radiology, Washington Univ., St. Louis, MO |
| Primary Theme and Topics |
Cognition and Behavior - Human Cognition and Behavior -- Other higher functions |
| Secondary Theme and Topics | Sensory Systems<br />- Vision<br />-- Subcortical visual pathways |
| Session: |
83. Human cognition and behavior: other higher functions I Poster |
| Presentation Time: | Sunday, November 11, 2001 10:00 AM-11:00 AM |
| Location: | Exhibit Hall TT-32 |
| Keywords: | connection, MRI, amygdala, vision |
Objective
To evaluate the reliability of MRI diffusion tensor tracking (DTT) of the amygdalo-calcarine pathway and for general neuroscience studies.
Introduction
DTT provides a means to assess white matter (WM) connections in living humans by tracing water diffusion. To use DTT, it is important to know its reliability.
Methods
We quantified vector distance errors by numerical simulation of the DTT procedures for an analytical curved pathway. We also assessed experimental reproducibility across subjects.
Results
Errors in track location at 6cm were 0.04±0.08mm (N=30) for standard conditions. The variance V of the error distance was proportional to track length L for almost all experimental conditions, with α=V/L strongly dependent on SNR, number of averages, and WM anisotropy. To gauge reproducibility, the amygdalo-calcarine tract involved in emotional modulation of visual perception was replicated across subjects, including a tight curve at the amygdala (arrows in Figure).
Conclusion
DTT errors have a predictable dependence on experimental conditions, which may enable neuroscientists to estimate errors with knowledge of only a few experimental parameters. Results are replicated across subjects for the long complexly-shaped amygdalo-calcarine pathway.
To evaluate the reliability of MRI diffusion tensor tracking (DTT) of the amygdalo-calcarine pathway and for general neuroscience studies.
Introduction
DTT provides a means to assess white matter (WM) connections in living humans by tracing water diffusion. To use DTT, it is important to know its reliability.
Methods
We quantified vector distance errors by numerical simulation of the DTT procedures for an analytical curved pathway. We also assessed experimental reproducibility across subjects.
Results
Errors in track location at 6cm were 0.04±0.08mm (N=30) for standard conditions. The variance V of the error distance was proportional to track length L for almost all experimental conditions, with α=V/L strongly dependent on SNR, number of averages, and WM anisotropy. To gauge reproducibility, the amygdalo-calcarine tract involved in emotional modulation of visual perception was replicated across subjects, including a tight curve at the amygdala (arrows in Figure).
Conclusion
DTT errors have a predictable dependence on experimental conditions, which may enable neuroscientists to estimate errors with knowledge of only a few experimental parameters. Results are replicated across subjects for the long complexly-shaped amygdalo-calcarine pathway.
Supported by NIH R01 NS39538 and P01 NS06833
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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