Neuroscience 2004 Abstract
| Presentation Number: | 771.4 |
|---|---|
| Abstract Title: | Medial prefrontal cortex lesions disrupted acquisition of appetitive signaled barpressing. |
| Authors: |
Reimers, J. M.*1,2
; Richards, K. A.4
; Chapleau, C. A.5
; Miller, D. P.2,3
1Biol., Carthage Col., Kenosha, WI 2Neuro., Carthage Col., Kenosha, WI 3Psyc., Carthage Col., Kenosha, WI 4WI, 2001 Alford Park Dr., 53140, 5USA, 2001 Alford Park Dr., 53140, |
| Primary Theme and Topics |
Cognition and Behavior - Human and Animal Cognition and Behavior -- Associative, nonassociative and skill learning & memory systems |
| Session: |
771. Prefrontal Cortex Poster |
| Presentation Time: | Tuesday, October 26, 2004 4:00 PM-5:00 PM |
| Location: | San Diego Convention Center - Hall A-H, Board # II27 |
| Keywords: | IBOTENIC ACID, INSTRUMENTAL LEARNING, INFRALIMBIC CORTEX |
In appetitive signaled barpressing (ASB) rats learn to press a bar during a 1 sec tone for food pellet reinforcement. Garraghty and colleagues have demonstrated that antiepileptic drugs and lesions of the NBM disrupted transfer from ASB to an aversive form of the task but did not disrupt the initial acquisition of the appetitive task (e.g., Butt et. al., IP&BS, 38, 2003). A number of studies suggest that the medial prefrontal cortex (mPFC) is necessary for performance in a variety of learning tasks. For example, coincident blocking of NMDA and dopamine D1 receptors in the mPFC disrupted acquisition on an appetitive instrumental task (Baldwin et. al., J. Neurosci., 22, 2002) and antagonism of NMDA receptors in the mPFC impaired trace conditioning in rabbit eyelid conditioning (Takehara et. al., SFN Abstracts, 81.11, 2003). Lesions of the mPFC impaired memory in a water maze task (Kim & Baxter, SFN Abstracts, 940.8, 2003) and blocked recall of extinction in a conditioned fear task (Quirk et. al., J. Neurosci., 20, 2000). Our study examined the involvement of the mPFC in acquisition of the instrumental ASB task. Rats received ibotenic acid lesions of the mPFC after training on a FR4 schedule. In agreement with previous research, rats with lesions of the mPFC that included the infralimbic (IL) region failed to acquire reinforced responding over 15 d of ASB training compared to sham operated rats. Lesions of the mPFC that spared most of the IL cortex delayed but did not prevent acquisition of reinforced responding on the ASB task. Post lesion performance on the FR4 task (100 pellets in 45 min) was not affected by either lesion. Current research is examining whether the mPFC lesions disrupted acquisition of signaled barpressing per se or disrupted ability to shift response strategy from FR4 to ASB responding.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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