Neuroscience 2002 Abstract
| Presentation Number: | 858.17 |
|---|---|
| Abstract Title: | Diminished cerebellar and hippocampal responses to a cold pressor challenge in heart failure patients revealed by functional magnetic resonance imaging. |
| Authors: |
Harper, R. M.*1
; Woo, M. A.3
; Macey, P. M.1
; Macey, K. E.1
; Henderson, L. A.1
; Frysinger, R. C.1
; Harper, R. K.1
; Yan-Go, F. L.2
; Alger, J. R.4
1Dept Neurobiology, UCLA, Los Angeles, CA 2Dept Neurology, UCLA, Los Angeles, CA 3School of Nursing, UCLA, Los Angeles, CA 4Radiological Sciences, UCLA, Los Angeles, CA |
| Primary Theme and Topics |
Autonomic, Limbic and Other Systems - Autonomic -- Cardiovascular regulation |
| Secondary Theme and Topics | Autonomic, Limbic and Other Systems<br />- Biological Rhythms and Sleep |
| Session: |
858. Autonomic: cardiovascular regulation II Poster |
| Presentation Time: | Thursday, November 7, 2002 8:00 AM-9:00 AM |
| Location: | Hall A2-B3 H-19 |
| Keywords: | SLEEP, BLOOD PRESSURE, CARDIOVASCULAR, RESPIRATION |
Heart failure patients (HF) exhibit deficient heart rate variability patterns during sleep, inappropriate blood pressure responses to evoked challenges, and sleep-disordered breathing patterns, suggesting central regulatory disturbances of autonomic and respiratory control. We examined signal changes in neural sites recruited during a cold pressor challenge to the forehead. A series of 20 image slices (25 volumes, Echo Planar technique) through the brain of 5 HF patients (32-59 yrs), all with sleep-disordered breathing, and 20 healthy control subjects (29-66 yrs) was collected during 1 min baseline and 1.5 min application of a bag of cold (3°C) deuterium oxide to the forehead in a GE 1.5T Signa scanner. Images collected during baseline and challenge conditions were spatially normalized and subjected to a random-effects analysis using the SPM imaging package. Signal changes were significantly diminished in paravermal cerebellar and hippocampal areas of HF patients over controls. We speculate that cerebellar and hippocampal dysfunction contributes to the progressive autonomic deterioration found in HF, possibly by failure to appropriately regulate blood pressure patterning during sleep disordered breathing. .
Supported by NHLBI HL-60296
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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