Neuroscience 2002 Abstract
| Presentation Number: | 857.9 |
|---|---|
| Abstract Title: | MRI demonstration of reinnervation of muscle by sprouting from a severed nerve in a human subject. |
| Authors: |
Filler, A. G.*1
1Inst Nerve Medicine, Santa Monica, CA |
| Primary Theme and Topics |
Motor Systems - Muscle and Motor Unit |
| Session: |
857. Muscle and motor unit: compartments and innervation Poster |
| Presentation Time: | Thursday, November 7, 2002 8:00 AM-9:00 AM |
| Location: | Hall A2-B3 H-8 |
| Keywords: | Nerve injury, regeneration , MR Neurography |
Reinnervation of muscle typically does not take place if a main motor nerve is severed. Regrowing nerve is thought to depend on travel within an existing conduit such as a nerve graft or one provided by suture to the denervated distal portion of the nerve.
A teenage patient who suffered a complete laceration of the sciatic nerve demonstrated partial recovery from paralysis five months after the injury although there had been no effort to repair or graft the nerve.
High resolution magnetic resonance neurography demonstrated that new distal nerve had sprouted from the truncated terminus of the cut sciatic nerve and reached an adjacent portion of the hamstring muscle mass, traveling a distance of more than six centimeters to reach its target.
Demonstration of this class of nerve regrowth and muscle reinnervation suggests that denervated role can play a significant role in directing the regrowth of severed nerves in human subjects.
A teenage patient who suffered a complete laceration of the sciatic nerve demonstrated partial recovery from paralysis five months after the injury although there had been no effort to repair or graft the nerve.
High resolution magnetic resonance neurography demonstrated that new distal nerve had sprouted from the truncated terminus of the cut sciatic nerve and reached an adjacent portion of the hamstring muscle mass, traveling a distance of more than six centimeters to reach its target.
Demonstration of this class of nerve regrowth and muscle reinnervation suggests that denervated role can play a significant role in directing the regrowth of severed nerves in human subjects.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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