Neuroscience 2001 Abstract
| Presentation Number: | 826.1 |
|---|---|
| Abstract Title: | Pharmacological MRI Mapping of Age-associated Changes in Basal Ganglia Circuitry of Awake Rhesus Monkeys. |
| Authors: |
Zhang, Z. M.*1,2,3
; Anderseb, A.1,2,3
; Grondin, R.1,2,3
; Avison, R.3
; Barber, T.1
; Bognar, A.3
; Gerhardt, G.1,2,3
; Gash, D. M.1,2,3
1Anatomy and Neurobiology, University of Kentucky, Lexington, KY 2Morris K. Udall Parkinson's Disease Research Center of Excellence, University of Kentucky, Lexington, KY 3Magnetic Resonance Imaging and Spectroscopy, University of Kentucky, Lexington, KY |
| Primary Theme and Topics |
Motor Systems - Basal Ganglia -- Transmitters and receptors |
| Session: |
826. Basal ganglia: transmitters and receptors IV Poster |
| Presentation Time: | Wednesday, November 14, 2001 1:00 PM-2:00 PM |
| Location: | Exhibit Hall V-2 |
| Keywords: | Aging, Dopamine receptor, Basal ganglia, Pharmacological MRI |
While the pathological changes induced by the loss of dopamine innervation in the basal ganglia by Parkinson's disease are well studied, little is known about functional changes in the neural circuitry of this area during normal aging. Accordingly we have analyzed age-associated changes in the basal ganglia of behaviorally characterized, awake rhesus monkeys, using pharmacological MRI to map responses to dopaminergic stimulation. Apomorphine, a mixed D1/D2 dopamine receptor agonist, significantly reduced neural activity in the substantia nigra (SN) of young adult rhesus monkeys, while evoking little change in aged animals. Compared to young animals, both apomorphine and amphetamine (an indirect D1/D2 dopamine receptor agonist) significantly increased activation of the aged rhesus globus pallidus externa (GPe). In addition, the aged animals showed decreased activity in the putamen in response to amphetamine administration. The changes in SN, GPe and putamen activation are consistent with the concept that basal ganglia dopaminergic functions are significantly modified in the course of normal aging as well as during Parkinson's disease.
Supported by USPHS NIH grants AG13494, NS39787, and MH01245.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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