Neuroscience 2005 Abstract
| Presentation Number: | 752.12 |
|---|---|
| Abstract Title: | Comparing neuromodulator- and projection neuron-elicited oscillations: a modeling study. |
| Authors: |
Kintos, N.*1
; Nadim, F.1,2
1Math. Sci., New Jersey Inst. of Tech, Newark, NJ 2NJ, 606 Cullimore Hall, 07102-1982, |
| Primary Theme and Topics |
Sensory and Motor Systems - Pattern Generation and Locomotion -- Invertebrate pattern generation |
| Secondary Theme and Topics | Sensory and Motor Systems<br />- Invertebrate Sensory and Motor Systems<br />-- Invertebrate motor systems |
| Session: |
752. Invertebrate Pattern Generation II Poster |
| Presentation Time: | Tuesday, November 15, 2005 4:00 PM-5:00 PM |
| Location: | Washington Convention Center - Hall A-C, Board # DD25 |
| Keywords: | STOMATOGASTRIC, CENTRAL PATTERN GENERATOR, CRUSTACEA, NETWORK |
Neural networks can be directed to change their activity pattern when subjected to neuromodulation. We use modeling techniques to study neuromodulation of central pattern generators (CPGs) in the crab (C. borealis) stomatogastric ganglion (STG). The STG is innervated by projection neurons whose processes release neuromodulatory substances. The modulatory commissural neuron 1 (MCN1) is one such projection neuron whose activity elicits a gastric mill rhythm (GMR: freq ~ 0.1 Hz). The frequency of this GMR is strongly regulated by a synaptic input from the pyloric circuit (freq: ~ 1 Hz). Recent experimental work has shown that superfusion of the neuropeptide pyrokinin (PK) elicits a GMR in the isolated STG that mimics the MCN1-elicited GMR (Hertzberg et al., SFN Abstr 33:604.14). We build a 2D model of the MCN1-elicited rhythm that exploits the difference in time scales operating within the asymmetric, reciprocally inhibitory CPG of the GMR. We then remove the MCN1 input and investigate what types of currents, when induced by PK in the CPG neurons can activate a GMR that mimics the MCN1-elicited rhythm. We find that either (1) a slowly-inactivating plateau current (Iplat) or (2) a slow hyperpolarization-activated inward current (Ih) is sufficient to activate such a GMR. We also find two additional mechanisms whereby multiple PK-induced currents activate a GMR that reproduces the strong influence from the pyloric input. In particular, (3) a fast, voltage-dependent inward (Iproc) plus a slow outward (IK) current (both noninactivating) or (4) a fast inward Iproc and outward IK plus a slow inward Ih can activate such a GMR. We also examine the predictions of the 2D model in parallel with a more biophysically-detailed model. We conclude that a fast voltage-dependent current alone is not sufficient to activate a PK-elicited GMR and that a slow, voltage-dependent current is necessary.
Supported by NIH MH60605 (FN)
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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