Neuroscience 2002 Abstract
| Presentation Number: | 830.8 |
|---|---|
| Abstract Title: | CANNABINOID GENETICS AND BEHAVIOR. |
| Authors: |
Onaivi, E. S.*1,2
; Ishiguro, H.2
; Zhang, P.2
; Akinshola, B. E.3
; Lin, Z.2
; Darmani, N.4
; Leonard, C.1
; Hall, F. S.2
; Hope, B.2
; Uhl, G. R.2
1Biology, William paterson Univ, Wayne, NJ 2NIDA-IRP, Baltimore, MD 3Pharmacology, Howard University College of Medicine, Washington DC, DC 4Pharmacology, Kirksville College of Osteopathic Medicine, Kirksville, MO |
| Primary Theme and Topics |
Cognition and Behavior - Animal Cognition and Behavior -- Learning & memory: Invertebrates |
| Secondary Theme and Topics | Synaptic Transmission and Excitability<br />- G-Protein Linked Receptors<br />-- Metabotropic glutamate receptors |
| Session: |
830. G-protein linked receptors II Poster |
| Presentation Time: | Thursday, November 7, 2002 11:00 AM-12:00 PM |
| Location: | Hall A2-B3 C-36 |
| Keywords: | EPCS, DRUG ABUSE, SPLICE VARIANTS, TRANSCRIPT SIZE |
Significant progress has been achieved in cannabinoid research. However little information is available at the molecular level about cannabinoid receptor (Cnr)gene structure and regulation. We have continued studies on Cnr genetics and signaling in order to understand the role of the endocannabinoid physiological control system (EPCS). Using in-vivo and in-vitro techniques we present data on Cnr CB1 transcript size, SNPs, trinucleotide repeat and variants. The presence of Cnr CB1 protein and gene expression in the shrew brain and gut, mouse and rat brains and human blood is presented as further evidence for the existence of the EPCS. We constructed a graphical representation of Cnr phylogenetic tree and using gene bank entries deduced amino acid sequence alignments of CB1 and CB2 Cnrs in a number of species. In-vivo, there was decreased effects of THC in the Rotorod and plus-maze tests suggesting the interaction of EPCS with mu opiate receptor. Together our data reveals an elaborate network of this EPCS and it was concluded that understanding the EPCS in the human body and brain will contribute to elucidating its role in health and disease.
Supported by NIDA-IRP
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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