Neuroscience 2001 Abstract
| Presentation Number: | 783.3 |
|---|---|
| Abstract Title: | SIMULTANEOUS, <i>IN VIVO</i> VISUALIZATION OF AXONAL CONNECTIVITY AND FUNCTIONAL ACTIVITY IN CAT VISUAL CORTEX USING MRI. |
| Authors: |
Kim, D. S.*1
; Ronen, I.1
; Formisano, E.2
; Ugurbil, K.1
; Mori, S.3
; Goebel, R.2
1CMRR, Univ Minnesota Med Sch, Minneapolis, MN 2Dept. of Neurocognition, Univ. of Maastricht, Maastricht, The Netherlands 3Dept. of Radiology, Johns Hopkins University, Baltimore, MD |
| Primary Theme and Topics |
Sensory Systems - Vision -- Striate visual cortex: Functional organization and circuitry |
| Session: |
783. Vision: striate visual cortex--functional organization III Slide |
| Presentation Time: | Wednesday, November 14, 2001 1:30 PM-1:45 PM |
| Location: | Room 11B |
| Keywords: | fMRI, DTI, Visual cortex, Cat |
In vivo visualization of the brain's functional architecture using fMRI is ubiquitous these days. However, in order to understand the how of the brain's information processing, it is of central importance to map the pattern of the neuronal connectivity in the same non-invasive manner. In this study, we have utilized MR techniques to visualize the functional activity and the pattern of axonal connectivity from the same cortical site. Cats were anesthetized using standard protocols. Subsequently, ultra-high field (9.4Tesla) fMRI signals were obtained during visual stimulation. Consecutively, high-resolution Diffusion Tensor Imaging (DTI) was used to assess the pattern of the axonal connectivity with respect to the layout of the functional activity. The MR parameters for functional scans were:64x64x64 matrix; FOV=5x5x4cm3, TE/image TR=12ms/1.5s. For DTI, a 3D Spin-EchoEPI sequence was used. The diffusion weighting parameters were: Diffusion time=16 msec, gradient duration=6 msec and gradient strength=17gauss/cm. At each session, 7 data sets were acquired with the gradients applied in 7 different combinations. The results of our study suggest that high-resolution mapping of the axonal connectivity in cat visual cortex can be achieved in a non-invasive manner, thus enabling - for the first time - to correlate the pattern of functional activity with that of the underlying neuronal circuitry in a living animal.
Supported by NIH, The Keck Foundation, and the Human Frontier Science Program.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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