Neuroscience 2004 Abstract
| Presentation Number: | 712.5 |
|---|---|
| Abstract Title: | Functional MRI of vestibular cancellation. |
| Authors: |
van der Geest, J. N.*1
; Schraa-Tam, C. K.2
; van der Lugt, A.2
; Frens, M. A.1
1Neurosci., Erasmus MC, Rotterdam, The Netherlands 2Radiology, Erasmus MC, Rotterdam, The Netherlands |
| Primary Theme and Topics |
Sensory Systems - Vestibular -- Perception, posture and spatial orientation |
| Secondary Theme and Topics | Sensory Systems<br />- Vestibular<br />-- Vestibulo-ocular reflex |
| Session: |
712. Eye Movements: Pursuit, Ocular Following, and Vestibular Function Slide |
| Presentation Time: | Tuesday, October 26, 2004 2:00 PM-2:15 PM |
| Location: | San Diego Convention Center - Room 23A |
| Keywords: | CEREBELLUM, EYE MOVEMENT, FMRI, VISUAL |
In this study we investigated which brain structures are activated when the visual and vestibular systems receive contradictory head rotation information. Using a 1.5T scanner, we acquired T2* weighted single shot gradient echo EPI functional scans (TR/TE 3750/50ms, 124 volumes, matrix size 64x64, slice thickness 4mm) during a caloric stimulation paradigm (120 ml water of 20 degrees Celsius in 15 seconds). The image data was processed with SPM-99 on both single-subject and group analysis level. Each subject participated in two experiments, one with the eyes closed (vestibular input only) and one with the eyes open (vestibular and visual input). The caloric stimulation was quite effective and lead to a sense of rotation in all subjects, especially when the eyes were open. With the eyes closed, activation was seen in several cortical areas, corroborating previous reports in the literature, but not in the cerebellum. However, with the eyes open, activation was observed in several cortical areas, that partially overlap with those in the closed eyes experiment, as well as in the contralateral cerebellar oculomotor vermis (see figure; top: glass brain view, bottom: projections on the anatomical level on the axial cerebellar level). These results demonstrate the role of the cerebellum in human vestibular cancellation.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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