Neuroscience 2004 Abstract
| Presentation Number: | 693.9 |
|---|---|
| Abstract Title: | Calibrating functional MRI data across subjects and scan sites. |
| Authors: |
Foland, L. C.*1
; Thomason, M. E.2
; BIRN, F.3
; Glover, G. H.1,2
1Radiology Dept., Stanford Univ., Stanford, CA 2Neurosciences Program, Stanford Univ., Stanford, CA 3MD, Brain Research Institute, |
| Primary Theme and Topics |
Cognition and Behavior - Human Cognition, Behavior, and Anatomy -- Genetic Variation and individual differences |
| Secondary Theme and Topics | Techniques in Neuroscience<br />- Data analysis, physiological methods, statistics |
| Session: |
693. Imaging Techniques: fMRI and Other Poster |
| Presentation Time: | Tuesday, October 26, 2004 8:00 AM-9:00 AM |
| Location: | San Diego Convention Center - Hall A-H, Board # FFF17 |
| Keywords: | COGNITION, BRAIN IMAGING, CEREBRAL BLOOD FLOW, NEUROIMAGING |
The FIRST (Functional Imaging Research Schizophrenia Testbed) Biomedical Informatics Research Network (fBIRN) program is the first-ever large scale, multi-center fMRI study of schizophrenia (http://www.nbirn.net). To accurately pool fMRI scan data across sites of different field strengths, scanner manufactures and pulse sequence types, a calibration protocol was implemented in which 5 normal volunteers were scanned at each of the 11 participating fBIRN sites. We present the initial results of a subset of this data and compare activation results from a sensorimotor (SM) and hypoxic challenge or breath-hold (BH) task (which putatively measures vascular responsivity devoid of cognition). Because cerbral perfusion is a filter through which neural events are interpreted in fMRI, measures of BOLD signal taken from BH scans were used to normalize activation data from cognitive SM tasks between subjects and sites. Subject dependent ROIs in visual, auditory and motor cortices were defined using activation maps from the first SM task run of each scan session and used to interrogate percent activation in BH scans. Percent BOLD signal was obtained with Fourier analysis of the timeseries signal by averaging over all activated voxels. These values were averaged (4 SM and 2 BH scans), to give one SM-BH data pair for each session and ROI. In a grouped linear regression, an R2 value of 0.490 for SM vs. BH was obtained, suggesting a good correlation between the non-cognitive BH task and the SM task. However, normalization of SM by BH yielded no decrease in variance in SM, and suggests the SM task has additional variance that cannot be explained by vascular differences. Supported by the NIH NCRR FIRST BIRN (RR00827-28), RR09784, MH63576, Lucas Foundation and GEMS.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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