Neuroscience 2002 Abstract
| Presentation Number: | 783.13 |
|---|---|
| Abstract Title: | Supraspinal Versus Spinal SR141716A Antagonism Of Delta-9-Tetrahydrocannabinol Antinociception And Catalepsy In Male And Female Rats. |
| Authors: |
Tseng, A. H.*1
; Craft, R. M.2
1Graduate Program in Pharmacology/Toxicology, Washington State University, Pullman, WA 2Department of Psychology, Washington State University, Pullman, WA |
| Primary Theme and Topics |
Cognition and Behavior - Behavioral Pharmacology -- Other |
| Secondary Theme and Topics | Sensory Systems<br />- Pain<br />-- Developmental aspects, growth factors and gender differences |
| Session: |
783. Behavioral pharmacology V Poster |
| Presentation Time: | Wednesday, November 6, 2002 1:00 PM-2:00 PM |
| Location: | Hall A2-B3 P-25 |
| Keywords: | SEX DIFFERENCES, CANNABINOIDS, INTRATHECAL, INTRACEREBROVENTRICULAR |
Recently our lab demonstrated that delta-9-tetrahydrocannabinol (THC) was more potent or efficacious producing antinociception and catalepsy in female rats than in male rats. The purpose of this study was to determine if sex differences in THC-induced antinociception or catalepsy are due to sex differences in the contribution of supraspinal versus spinal cannabinoid receptor 1 (CB1) activation. SR141716A, a selective CB1 receptor antagonist, or vehicle was administered i.c.v. or i.t.; the time course of SR141716A antagonism of 10 mg/kg i.p. THC or vehicle-induced antinociception (paw pressure test) and catalepsy (bar test) were determined. Baseline antinociceptive and cataleptic scores were similar between the sexes in all groups. THC alone produced similar antinociception in males and females but produced greater catalepsy in females. SR141716A alone did not produce any significant effects. I.c.v. SR141716A did not significantly antagonize systemic THC-induced antinociception, but significantly antagonized THC-induced catalepsy to similar degrees in both sexes. I.t. SR141716A significantly antagonized THC-induced antinociception and catalepsy, similarly in both sexes. These results suggest that THC-induced antinociception against mechanical stimulus-induced pain is mediated to a greater degree by spinal CB1 receptors than supraspinal CB1 receptors, in rats of both sexes. In contrast, THC-induced catalepsy is mediated to a similar degree by supraspinal and spinal CB1 receptors, in rats of both sexes.
Supported by NIDA grant DA06036
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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