Neuroscience 2002 Abstract
| Presentation Number: | 783.11 |
|---|---|
| Abstract Title: | PERIPHERAL THC ADMINISTRATION AND FOOD INTAKE: EFFECTS OF PREFEED DURATION AND INTERACTIONS WITH NALOXONE. |
| Authors: |
Koch, J. E.*1
; Gorgati, C.2
; Kirkham, T. C.2
1Dept Psychol, Univ Wisconsin, Oshkosh, Oshkosh, WI 2Dept Psychol, Univ Reading, Reading, United Kingdom |
| Primary Theme and Topics |
Cognition and Behavior - Behavioral Pharmacology -- Other |
| Session: |
783. Behavioral pharmacology V Poster |
| Presentation Time: | Wednesday, November 6, 2002 3:00 PM-4:00 PM |
| Location: | Hall A2-B3 P-25 |
| Keywords: | cannabinoids, opioids, eating, rat |
The ability of THC and endocannabinoids to stimulate food intake in rats has been demonstrated in recent studies using both peripheral and central administration and a variety of food types. Potential changes in motivational states have been hypothesized to account for some of the cannabinoid-related effects on ingestion. In addition, interactions between cannabinoid and opioid systems that impact ingestive states appear to exist, with synergistic suppression of intake following concurrent administration of antagonists for both CB1 and opioid receptors. The current set of studies first attempted to manipulate the motivational state of Lewis rats by varying the length of pre-drug exposure (prefeed) to food (chocolate cake batter). Duration of prefeed had a pronounced effect on orally-administered THC's ability to stimulate food intake, particularly in comparison to intake following vehicle. Following establishment of a prefeed paradigm in which THC produced reliable significant increases, the ability of, naloxone, to dose-dependently affect THC-induced intake was investigated. The opiate antagonist significantly suppressed THC-induced cumulative intake for up to 2 h following, while interval intake suppression was limited to the 0.5-1h time period only. The data are discussed with respect to rat strain & responsiveness to drugs, ingestion-related motivational states, type of food used, and the effects on ingestion of interactions between cannabinoid and opioid systems.
Supported by Work supported by the Univ. WI Oshkosh Psychology Dept. & the Medical Research Council, Univ. Reading.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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