Neuroscience 2004 Abstract
| Presentation Number: | 690.15 |
|---|---|
| Abstract Title: | Tolerance and dependence to δ<sup>9</sup>-tetrahydrocannabinol in rhesus monkeys discriminating a cannabinoid antagonist (SR 141716A). |
| Authors: |
Amin, M. R.*1
; France, C. P.1
; McMahon, L. R.1
1Dept. of Pharmacol., Univ. of Texas Hlth. Sci. Ctr. at San Antonio, San Antonio, TX |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Addiction and Drugs of Abuse -- Cannabinoids |
| Session: |
690. Drugs of Abuse: Cannabinoids Poster |
| Presentation Time: | Tuesday, October 26, 2004 10:00 AM-11:00 AM |
| Location: | San Diego Convention Center - Hall A-H, Board # EEE10 |
| Keywords: | WITHDRAWAL, CA1, CA3, TEMPERATURE |
Marijuana (Cannabis sativa) is widely used and can produce dependence as evidenced by withdrawal symptoms upon discontinuation of use. In order to examine tolerance and dependence to the main psychoactive component in marijuana (Δ9-tetrahydrocannabinol, Δ9-THC), the cannabinoid antagonist SR 141716A has been established as a discriminative stimulus in rhesus monkeys treated with 0.56 mg/kg/day of Δ9-THC. Other dependent measures, including directly observable (e.g. eye closing and head shaking) and physiological measures (e.g. body temperature), were assessed in this study to establish whether tolerance and dependence developed to Δ9-THC in the same monkeys (n = 4) that discriminate SR 141716A compared to another group of monkeys (n = 4) that had not received daily Δ9-THC. Acute Δ9-THC (0.56 mg/kg) increased eye closing and decreased body temperature in all monkeys (-1.0 ± 0.2 oC), and these effects were significantly greater in untreated monkeys compared to Δ9-THC-treated monkeys. SR 141716A (3.2 mg/kg) attenuated the effects of Δ9-THC on eye closing in both groups. Discontinuation of Δ9-THC treatment for 24 h increased head shaking that was further increased by SR 141716A, whereas SR 141716A induced less head shaking in untreated monkeys. The decreased sensitivity to some of the direct effects of Δ9-THC in Δ9-THC-treated monkeys, relative to untreated monkeys, suggests that tolerance developed to some effects of Δ9-THC in Δ9-THC-treated monkeys discriminating SR 141716A. Head shaking that occurs after discontinuation of Δ9-THC treatment and after administration of SR 141716A in Δ9-THC-treated monkeys appears to be a prominent sign of Δ9-THC withdrawal. Collectively, these results indicate that monkeys discriminating SR 141716A are tolerant and dependent to Δ9-THC.
Supported by USPHS DA15468
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
Copyright © 2004-2025 Society for Neuroscience; all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
