Neuroscience 2004 Abstract
| Presentation Number: | 690.3 |
|---|---|
| Abstract Title: | Deficits in a rodent attentional set-shifting task induced by repeated THC administration. |
| Authors: |
Allison, C.*1
; Brett, R. R.1
; Pratt, J. A.1
1Physiology and Pharmacol., Univ. of Strathclyde, Glasgow, United Kingdom |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Addiction and Drugs of Abuse -- Cannabinoids |
| Secondary Theme and Topics | Cognition and Behavior<br />- Human and Animal Cognition and Behavior<br />-- Executive function |
| Session: |
690. Drugs of Abuse: Cannabinoids Poster |
| Presentation Time: | Tuesday, October 26, 2004 10:00 AM-11:00 AM |
| Location: | San Diego Convention Center - Hall A-H, Board # EEE10 |
| Keywords: | cannabinoid, prefrontal cortex, cognitive |
Cannabis use has been associated with deficits in prefrontal- cortex dependent cognitive processes in humans. We have previously shown that acute administration of Δ9-tetrahydrocannabinol (THC) produces deficits in reversal learning (REV) and the ability to shift attention within a perceptual dimension (intradimensional shift, IDS) in an attentional set shifting task (ASST) (Egerton et al., Program No. 110.15 2003 Abstract viewer/Itinerary Planner. Washington, DC: Society for Neuroscience). However, the human literature suggests that cannabis-induced cognitive deficits are more apparent following chronic use. We therefore employed the ASST to test the hypothesis that a chronic intermittent THC treatment regime would lead to deficits in executive function that were different from those induced by acute treatment.
Long Evans hooded rats were administered THC (1mg/kg i.p.) or vehicle once per week for 4 weeks and tested in the ASST 30 minutes after the last dose of THC or vehicle. Chronic intermittent THC produced significant deficits in the ability to shift attention both within [(IDS), trials to criterion: VEH: 7.9 ± 0.38, THC: 10.4 ± 1.02; p=0.03] and between [(EDS), trials to criterion : VEH: 8.7 ± 0.76, THC: 11.2 ± 0.84; p=0.04] perceptual dimensions in the ASST. THC treatment did not significantly affect performance in any of the other discriminations comprising the task, including the reversal discriminations. These data indicate that with chronic intermittent THC treatment there is an emerging deficiency in the EDS but tolerance to the acute effects on reversal learning. THC-induced neuroadaptive alterations in prefrontal circuitry may underlie these effects of chronic intermittent treatment on behavioural flexibility.
Long Evans hooded rats were administered THC (1mg/kg i.p.) or vehicle once per week for 4 weeks and tested in the ASST 30 minutes after the last dose of THC or vehicle. Chronic intermittent THC produced significant deficits in the ability to shift attention both within [(IDS), trials to criterion: VEH: 7.9 ± 0.38, THC: 10.4 ± 1.02; p=0.03] and between [(EDS), trials to criterion : VEH: 8.7 ± 0.76, THC: 11.2 ± 0.84; p=0.04] perceptual dimensions in the ASST. THC treatment did not significantly affect performance in any of the other discriminations comprising the task, including the reversal discriminations. These data indicate that with chronic intermittent THC treatment there is an emerging deficiency in the EDS but tolerance to the acute effects on reversal learning. THC-induced neuroadaptive alterations in prefrontal circuitry may underlie these effects of chronic intermittent treatment on behavioural flexibility.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
Copyright © 2004-2025 Society for Neuroscience; all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
