Neuroscience 2001 Abstract
| Presentation Number: | 753.4 |
|---|---|
| Abstract Title: | <b>VIGABATRIN (VGB), A GABA TRANSAMINASE INHIBITOR, CAUSED INCREASED HYPEREXCITABILITY FOLLOWING STIMULUS-EVOKED AFTERDISCHARGES (SEADs) IN RATS.</b> |
| Authors: |
Kerstetter, A. E.*1,2
; Parks, A. H.1,2
; Quinn, D. L.1,2
1Biology, Muskingum College, New Concord, OH 2Neuroscience Program, Muskingum College, New Concord, OH |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Epilepsy -- Anti-cunvulsant drugs |
| Session: |
753. Epilepsy: anticonvulsant drugs--electrophysiology Poster |
| Presentation Time: | Wednesday, November 14, 2001 11:00 AM-12:00 PM |
| Location: | Exhibit Hall UU-60 |
| Keywords: | EPILEPSY, BRAIN SLICE, HIPPOCAMPUS, HYPEREXCITABILITY |
Visual field constriction and a significantly higher incidence of depression and psychosis may appear as side effects of vigabatrin treatment. Our research, using the rat hippocampal slice, revealed that VGB failed to alter the length SEADs. In contrast, VGB lowered the frequency of spontaneous discharges while increasing the excitability of CA1 cells ( Carrel et al, 1998, SFN Abstract 769.1 ). The current research examined the action of VGB on acute pyramidal cell activity, following SEADs, and after LTP-LTP-weak LTD stimulus sequence in the hippocampal CA1. Electrical stimulation through a bipolar electrode placed in the Schaffer collaterals activated CA1 pyramidal cells. Only acute treatment of CA1 cells with bicuculline ( 50uM ) caused multiple spiking . VGB ( 250 or 500uM ) failed to induce multiple spikes during the short recording time. SEADs were initiated in hippocampal slices in the CA1 region exposed to either normal ACSF or HiK Low MG ACSF. No significant differences were noted. On the other hand, when VGB was added to normal ACSF and responses compared to slices in normal ACSF, a significant increase in multiple spiking occurred. VGB ( 250uM ) placed in the pool beneath the hippocampal slices for 90 minutes failed to significantly alter hyperexcitability when compared to slices only exposed to HiK Low MG ACSF. However, increasing the dose of VGB to 500uM significantly increased multiple spiking. Conclusion: Under the current experimental conditions, vigabatrin induced hyperexcitability rather than inhibition in CA1 pyramidal cells.
Supported by Supported by the Muskingum College Faculty Development Fund
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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