Neuroscience 2002 Abstract
| Presentation Number: | 775.18 |
|---|---|
| Abstract Title: | The cannabinoid receptor agonist, CP 55,940, influences rat feeding when injected into the 4th ventricle. |
| Authors: |
Miller, C. C.*1
; Murray, T. F.1
; Edwards, G. L.1
1Physiology and Pharmacoloogy, University of Georgia, Athens, GA |
| Primary Theme and Topics |
Autonomic, Limbic and Other Systems - Regulation of Food Intake and Body Weight |
| Session: |
775. Regulation of food intake and body weight: peptide and cannabinoid regulators Poster |
| Presentation Time: | Wednesday, November 6, 2002 2:00 PM-3:00 PM |
| Location: | Hall A2-B3 L-20 |
| Keywords: | food intake, hindbrain, medulla, reward |
Cannabinoids have been shown to influence food intake, and until recently, the neural pathways mediating these effects have remained obscure. It has been previously shown that i.c.v. injection of Δ9-THC causes increased consumption of palatable foods in rats (Koch an Matthews, 2001), and we postulated the involvement of the hindbrain in this cannabinoid-induced food intake. Cannulated rats (both female and male groups) trained to consume sweetened condensed milk received either lateral or 4th ventricle injections of CP 55,940 and were presented with sweetened condensed milk 15 minutes after injection. All rats were injected over a range of doses between 10 pg and 10 μg per rat. Milk intake was recorded every 10 minutes for 30 minutes and then every hour thereafter for a total of 3 hours. Lateral ventricle injection of CP 55,940 increased milk intake and induced c-fos immunoreactivity in the region of the rostral 4th ventricle at doses in the microgram range; however, CP 55,940 was effective in increasing food intake at nanogram doses when injected into the 4th ventricle. An influence of gender was evinced by the observation that 4th ventricle cannulated male rats appeared to be sensitive to CP 55,940 than female rats inasmuch as milk consumption was increased at the 1 ng dose in male rats whereas only the 10 ng dose was effective in females. These results indicate that CP 55,940 may act in the hindbrain to influence feeding behavior in rats.
Supported by NIH DA14165
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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