Neuroscience 2004 Abstract
| Presentation Number: | 682.3 |
|---|---|
| Abstract Title: | The relation of MRI-derived normalized whole brain volume and cerebrovascular disease markers with cognitive function in ischemic stroke patients. |
| Authors: |
Wang, C.*1
; Sripathirathan, K.1
; Nyenhuis, D. L.3
; Freels, S.4
; Gencheva, E.3
; Turner, D. A.2
; Gorelick, P. B.3
; deToledo-Morrell, L.1
1Dept of Neurol Sci, Rush Univ. Med Ctr., Chicago, IL 2Dept of Radiol, Rush Univ. Med Ctr., Chicago, IL 3IL, 1735 W. Harrison St., 60612, 4USA, 1735 W. Harrison St., 60612, |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Ischemia -- Global Ischemia |
| Session: |
682. Global Ischemia III Poster |
| Presentation Time: | Tuesday, October 26, 2004 10:00 AM-11:00 AM |
| Location: | San Diego Convention Center - Hall A-H, Board # YY17 |
| Keywords: | MRI structure, cognition, Ischemia |
Ischemia causes long-term effects on brain volume and cognitive function, but the relationship between the two is poorly characterized and conflicting. Some studies found whole brain volume to be associated with deficits in cognitive function, while others did not. In the present study, we investigated the relation of MRI-derived normalized whole brain volume and cerebrovascular disease markers with cognitive performance in ischemic stroke patients. 108 subjects with ischemic stroke were included. Cognitive function was evaluated with tests covering global cognitive status, memory, attention, spatial reasoning, language and psychomotor skills. MRI scans were acquired in a 1.5T scanner using a T1 weighted 3D SPGR pulse sequence. Whole brain (WBV), total intracranial (TIV), lateral ventricle (LVV) and stroke (STV) volumes were derived with the Analyze software (Mayo Clinic, Rochester, MN). WBVs were normalized by dividing with TIV. Ventricle-to-brain ratios (VBR) were calculated as a measure of atrophy. We found that normalized WBV did not correlate with most cognitive functions, except one memory test. Left STV inversely correlated with global cognitive (r=-0.518, p<0.01), spatial reasoning (r=-0.197, p=0.042), memory (r=-0.250 to -0.364, p<0.05) and language (r=-0.357, p<0.01) tests, while right STV inversely correlated with spatial reasoning (r=-0.224, p=0.021) and psychomotor (r=-0.24, p=0.022) tests. VBRs negatively correlated with all cognitive tests (r=-0.212 to -0.397, p<0.05) except spatial reasoning (r=0.02, p=0.841). These findings suggest that measures of cerebrovascular disease burden and atrophy as indexed by VBR relate better to cognitive performance than WBV.
Supported by AG17934
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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