Neuroscience 2005 Abstract
| Presentation Number: | 54.8 |
|---|---|
| Abstract Title: | Neuromodulation of the two components of a single synapse in a rhythmic network. |
| Authors: |
Zhao, S.*1
; Zhou, L.1
; Nadim, F.1
1Biology , Rutgers Univ., Newark, NJ |
| Primary Theme and Topics |
Sensory and Motor Systems - Pattern Generation and Locomotion -- Invertebrate pattern generation |
| Secondary Theme and Topics | Neural Excitability, Synapses, and Glia: Cellular Mechanisms<br />- Synaptic Plasticity<br />-- Short-term plasticity |
| Session: |
54. Invertebrate Pattern Generation I Poster |
| Presentation Time: | Saturday, November 12, 2005 4:00 PM-5:00 PM |
| Location: | Washington Convention Center - Hall A-C, Board # W19 |
| Keywords: | STOMATOGASTRIC, NEUROMODULATION, SYNAPTIC PLASTICITY, CALCIUM CURRENT |
Network plasticity arises in large part due to the effects of exogenous neuromodulators, many of which modify synaptic transmission. The rhythmically active pyloric network of the crab C. borealis is a well-characterized CPG and is subject to extensive neuromodulation. We investigate the effects of the neuropeptide proctolin on the dynamics of the inhibitory synapse from the LP to the PD neuron in the pyloric network of the crab C. borealis. This synapse has both spike-mediated and non-spike-mediated (graded) components and is the only chemical feedback to the pyloric pacemaker neurons. Previous studies in our lab have shown that, in the presence of proctolin, low-amplitude presynaptic pulses cause the graded component to facilitate (Atamturktur et al, SFN Abst 657.18, 2004). We show that this facilitation is correlated with the activation of a presynaptic inward current. This inward current is blocked by Mn++, suggesting that it is a slowly-accumulating Ca++ current activated by proctolin. We also characterize the effects of proctolin on the spike-mediated component. We find that proctolin strengthens the spike-mediated IPSP and enhances its facilitation. We aim to determine the combined effects of proctolin on both synaptic components in the ongoing pyloric rhythm and propose that these combined effects contribute to the effects of proctolin at the network level.
Supported by NIH MH60605 (FN)
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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