Neuroscience 2005 Abstract
| Presentation Number: | 688.8 |
|---|---|
| Abstract Title: | Capturing connectional information: an MRI-based anatomical reference system. |
| Authors: |
Kennedy, D. N.*1
; Kaiser, J. R.1
; Albaugh, M. D.1
; Normandin, J. J.1
; Papadimitriou, G. M.1
; Jackson, J. S.1
; Davis, O. C.1
; Hodge, S. M.1
; Tulloch, S. N.1
; Boriel, D. L.1
; Haselgrove, C.1
; Piennar, R.1
; Tang, L.1
; Howard, J. D.1
; Caviness Jr., V. S.1
; Makris, N.1
; Yeterian, E. H.2
1Dept Neurol, Massachusetts General Hospital, Charlestown, MA 2ME, 149 13th Street, Room 6014, 02129, |
| Primary Theme and Topics |
Techniques in Neuroscience - Computation and Simulation |
| Session: |
688. Computational and Simulation Techniques II Poster |
| Presentation Time: | Tuesday, November 15, 2005 11:00 AM-12:00 PM |
| Location: | Washington Convention Center - Hall A-C, Board # WW12 |
| Keywords: | CEREBRAL CORTEX, CONNECTION, MRI |
Introduction: One of the most important unsolved problems in neuroscience is the wiring diagram of the human brain. Different approaches have been used in an attempt to elucidate the connections in the cerebrum in terms of their topographic arrangement [1] as well as in the forms of matrices [2]. Our group has formulated an MRI-based topographic system of human cerebral connectivity [1]. In the present study a list of the connections of each cerebral parcellation unit (PU) has been compiled in matrix form. This connectivity matrix reflects the current body of experimental animal and human data.
Methods: To map the cerebral corticocortical, corticothalamic, corticostriatal, corticopontine, hippocampal-cortical and amygdala-cortical connectivity, a meta-analysis of relevant human and non-human primate literature was conducted. Coding of connections was as follows: “1” was assigned to U-fibers and short intragyral and juxtagyral (both intralobar and juxtalobar) connections, “2” was assigned to medium-range intralobar (non-juxtagyral) connections, and “3” was assigned to long-range connections (intra- and interlobar association, corticothalamic, corticostriatal, corticopontine, hippocampal-cortical and amygdala-cortical).
Results: 48 cortical, 7 thalamic, 10 striatal, one corticopontine, one hippocampal cortical, and one amygdala cortical PU matrices have been formulated.
Discussion: Cortical areas relate to other cortical and subcortical regions following a general scheme of connectivity, allowing for integrated functioning within the central nervous system. Knowledge of connections is relevant for formulating and testing hypotheses in cognitive and clinical neuroscience.
References:
1) Makris N et al., Neuroimage. 1999; 9(1): 18-45.
2) Stephan KE et al., Philos Trans R Soc Lond B: Biol Sci. 2001; 356(1412): 1159-86.
Methods: To map the cerebral corticocortical, corticothalamic, corticostriatal, corticopontine, hippocampal-cortical and amygdala-cortical connectivity, a meta-analysis of relevant human and non-human primate literature was conducted. Coding of connections was as follows: “1” was assigned to U-fibers and short intragyral and juxtagyral (both intralobar and juxtalobar) connections, “2” was assigned to medium-range intralobar (non-juxtagyral) connections, and “3” was assigned to long-range connections (intra- and interlobar association, corticothalamic, corticostriatal, corticopontine, hippocampal-cortical and amygdala-cortical).
Results: 48 cortical, 7 thalamic, 10 striatal, one corticopontine, one hippocampal cortical, and one amygdala cortical PU matrices have been formulated.
Discussion: Cortical areas relate to other cortical and subcortical regions following a general scheme of connectivity, allowing for integrated functioning within the central nervous system. Knowledge of connections is relevant for formulating and testing hypotheses in cognitive and clinical neuroscience.
References:
1) Makris N et al., Neuroimage. 1999; 9(1): 18-45.
2) Stephan KE et al., Philos Trans R Soc Lond B: Biol Sci. 2001; 356(1412): 1159-86.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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