Neuroscience 2000 Abstract
| Presentation Number: | 737.18 |
|---|---|
| Abstract Title: | Neonatal auditory activation detected by functional magnetic resonance imaging. |
| Authors: |
Anderson, A. W.*1,2
; Marois, R.1,2
; Peterson, B. S.1,2
; Colson, E. R.1,2
; Duncan, C. C.1,2
; Ehrenkranz, R. A.1,2
; Schneider, K. C.1,2
; Gore, J. C.1,2
; Ment, L. R.1,2
1Depts Diagnostic Imaging, Pediatrics, Neurology, Child Study & Neurosurgery, Yale Univ. Sch. Med, New Haven, 2Dept of Psychology, Vanderbilt Univ, Nashville, |
| Primary Theme and Topics |
F. Sensory Systems - 82. Auditory systems: central physiology |
| Secondary Theme and Topics | A. Development and Regeneration<br />- 19. Sensory systems |
| Session: |
737. Auditory systems: speech, language, imaging Poster |
| Presentation Time: | Wednesday, November 8, 2000 2:00 PM-3:00 PM |
| Location: | Hall G-J |
| Keywords: | Auditory, Neonatal, Imaging, Development |
The incidence of language disabilities among the survivors of newborn special care ranges from 10 - 30%, and the pathophysiology of this injury remains poorly explained. Because the central processing of auditory information is critical to the synthesis of language systems in the developing brain, we tested the hypothesis that functional MRI (fMRI) could detect neonatal auditory cortical activation. We performed echo-planar functional brain imaging on 9 non-sedated newborn infants at term. Subjects were presented with a frequency-modulated pure tone for 30 second epochs interleaved with 60 seconds of rest, and the BOLD signal response was mapped in five 5 mm-thick slices running parallel to the superior temporal gyrus. The same protocol was run on 4 healthy adult subjects. Conventional MRI structural imaging revealed no abnormalities for any of the subjects. BOLD signal in response to auditory stimulus was detected in all 4 adults and 8 of 9 neonates. fMRI studies of adult subjects demonstrated increased signal in the superior temporal regions bilaterally during auditory stimulation. In contrast, we detected signal decreases during auditory stimulation in 7 out of 8 newborns with a BOLD response. These data suggest that fMRI may be used to study language systems in developing brain and the relationship between oxygen extraction and tissue perfusion is different in adult and newborn brain.
Supported by (NS 27116)
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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