Neuroscience 2005 Abstract
| Presentation Number: | 674.8 |
|---|---|
| Abstract Title: | <i>In vivo</i> MRI and behavioral analyses of transgenic mice expressing the C-terminal truncated mutant DISC1 under the CaMKII promoter. |
| Authors: |
Hikida, T.*1
; Morita, M.2
; Pletnikov, M. V.2
; Xue, R.3
; Wu, D.2
; Ouyang, W.2
; Kida, S.4
; Mori, S.3
; Sawa, A.1,2
1Dept of Neurosci, Johns Hopkins Univ. School of Medicine, Baltimore, MD 2Dept of Psychiat, Johns Hopkins Univ. School of Medicine, Baltimore, MD 3Dept of Radiology, Johns Hopkins Univ. School of Medicine, Baltimore, MD 4Japan, 600 North Wolfe St, 21287, |
| Primary Theme and Topics |
Disorders of the Nervous System - Cognitive, Emotional and Behavioral State Disorders -- Schizophrenia: Pathology |
| Session: |
674. Pathology of Schizophrenia: Genes and Expression I Poster |
| Presentation Time: | Tuesday, November 15, 2005 11:00 AM-12:00 PM |
| Location: | Washington Convention Center - Hall A-C, Board # TT26 |
| Keywords: | schizophrenia, mutant, MRI, behavior |
Disrupted-in-schizophrenia-1 (DISC1), identified at the breakpoint of a chromosome (1;11)(q42.1; q14.3) translocation co-segregating with schizophrenia in a large Scottish family, is now a most promising candidate gene for schizophrenia. The translocation could lead to occurrence of the C-terminal truncated mutant DISC1 protein (mutDISC1). Our previous cellular and biochemical studies suggest that mutDISC1 acts in a dominant-negative fashion by directly associating with wild-type DISC1. Thus, overexpression of mutDISC1 can also provide a model of an overall loss of endogenous DISC1 function. To address function of DISC1 in vivo, especially its possible role in the pathophysiology of schizophrenia, we generated transgenic mice expressing mutDISC1 under the CaMKII promoter. Here we report the production of the mice and its characterization in vivo, such as neuroanatomical assessment with MRI and behavioral assays. Notably, we observed in the DISC1 transgenic mice enlargement of lateral ventricles that resembles that in brains of patients with schizophrenia. Age-dependent behavioral changes are now under investigation. We hope that the DISC1 transgenic mice serve as a novel rodent model for schizophrenia.
Supported by NIH, Stanley, S-R foundation, NARSAD
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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