Neuroscience 2005 Abstract
| Presentation Number: | 674.7 |
|---|---|
| Abstract Title: | Genetic variations of DISC1 affect the interaction between DISC1 and NUDEL. |
| Authors: |
Kamiya, A.*1
; Takaki, M.1
; Takanezawa, Y.3
; Paek, M.1
; Tomoda, T.4
; Arai, H.3
; Sawa, A.1,2
1Dept Psychiat, Johns Hopkins Univ., School of Medicine, Baltimore, MD 2Dept Neurosci, Johns Hopkins Univ., School of Medicine, Baltimore, MD 3Japan, 600 North Wolfe Street Meyer 4-163, 21287, 4Dept Health chem, 600 North Wolfe Street Meyer 4-163, 21287, |
| Primary Theme and Topics |
Disorders of the Nervous System - Cognitive, Emotional and Behavioral State Disorders -- Schizophrenia: Pathology |
| Session: |
674. Pathology of Schizophrenia: Genes and Expression I Poster |
| Presentation Time: | Tuesday, November 15, 2005 10:00 AM-11:00 AM |
| Location: | Washington Convention Center - Hall A-C, Board # TT26 |
| Keywords: | schizophrenia, Gene Expression, development, migration |
Accumulating evidence has suggested that DISC1 is involved in the neurodevelopment and pathophysiology of major mental illnesses, including schizophrenia. DISC1 binds with NUDEL (Ozeki et al 2003, PNAS), and regulates microtubule dynamics and neuronal migration (Kamiya et al, SFN abstract, 2004). Here we present a detailed study on the protein interaction of DISC1 and NUDEL. We clarified that a small domain in the C-terminal DISC1 (34 amino acids coded inside exon 13) is necessary for the DISC1/NUDEL binding, by co-immunoprecipitation with various mutants of DISC1 and NUDEL. We found that two common genetic variations that led to amino acid changes in the C-terminal DISC1 resulted in altered affinity of the DISC1/NUDEL protein binding. We are now investigating whether or not these genetic variants are associated with schizophrenia.
Supported by NIH, Stanley, S-R, and NARSAD
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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