Neuroscience 2003 Abstract
| Presentation Number: | 640.7 |
|---|---|
| Abstract Title: | Bispectral analysis of white matter lesions (wml) using t2w and 3D t1w MRI. |
| Authors: |
McKinstry, R. C.*1
; Sheline, Y. I.2
; Snyder, A. Z.1
; Moinuddin, A.1
; Christensen, J. J.1
; Mintun, M. A.1
1Radiology, Wash. Univ. Sch. of Med., St. Louis, MO 2Psychiatry, Wash. Univ. Sch. of Med., St. Louis, MO |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Psychiatric Disorders -- Affective disorders |
| Session: |
640. Depression: Pathology & Pathophysiology I Poster |
| Presentation Time: | Tuesday, November 11, 2003 10:00 AM-11:00 AM |
| Location: | Morial Convention Center - Hall F-I, Board # UU43 |
| Keywords: | DEPRESSION, AGING, MRI, LESION |
Reports suggest that depressed patients with more WMLs on T2W MRI have decreased response rates to antidepressant treatment, perhaps due to interruption of pathways involved in emotional regulation. To systematically identify WML number and location, we studied late-life depression using T2W and 3D T1W MRI. T2W scans were performed using 2D TSE: TR 4000ms, TE 97ms, 17 echoes, 2mm thickness, 10mm gap, 6 interleaves, 256x256x108, (1x1x2mm). Four separate sagittal 3D T1W scans were performed with MP-RAGE: TR 1900ms, TE 4ms, TI 1100ms, 222x256x128 (1x1x1.25mm). The T1W scans were coregistered to correct for head motion prior to averaging. The TSE scans were coregistered with the T1W scans and both were transformed into Talairach space. Parabolic gain field corrections were performed on both images to allow whole brain tissue type determination. A 2D histogram of pixel values was used to identify peaks for CSF, air, gray matter, white matter and two soft tissues. WML pixels were separated from both white and gray matter using an additional bispectral peak computed from the gray and white matter peaks. From these segmented images of tissue types, the volume and location of WML can be projected into atlas space for depression data sets.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
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