Neuroscience 2000 Abstract
| Presentation Number: | 704.1 |
|---|---|
| Abstract Title: | FK506 increases motor nerve regeneration after chronic axotomy but not after chronic Schwann cell denervation. |
| Authors: |
Sulaiman, O. A. R.*1
; Voda, J.2
; Gold, B. G.2
; Gordon, T.1
1Div Neurosci., Univ. of Alberta, Edmonton, Canada 2Ctr Res. Occup & Environ. Toxicol., Oregon Health Sci. Univ., Portland, OR |
| Primary Theme and Topics |
A. Development and Regeneration - 22. Regeneration |
| Secondary Theme and Topics | A. Development and Regeneration<br />- 6. Process outgrowth, growth cones and sprouting |
| Session: |
704. Regeneration X Poster |
| Presentation Time: | Wednesday, November 8, 2000 1:00 PM-2:00 PM |
| Location: | Hall G-J |
| Keywords: | Periheral nerve regeneration, Chronic nerve injury, Motor Functional recovery, Retrograde neuroanatomical tracers |
Poor functional recovery after peripheral nerve injury is attributable, at least in part, to chronic motoneuron axotomy (Fu & Gordon, JNS 15:3876,1995) and chronic Schwann cell (SC) denervation (Sulaiman & Gordon, JNS: submitted). FK506 accelerates the rate of nerve regeneration following sciatic nerve crush or immediate nerve repair via an action involving FKBP-52, a chaperone component of mature steroid receptor complexes (Gold et al., JPET 289:1202, 1999). However, for clinical application, it is important to determine whether FK506 is effective after chronic nerve injuries. Following 2 months chronic injury of adult rat proximal tibial (old TIB; chronic axotomy) or distal common peroneal (old CP; chronic SC denervation), old TIB-freshly cut distal CP or freshly cut TIB-old CP cross-sutures were performed and rats were given subcutaneous injections of FK506 (5mg/kg/day) for 3 weeks. In the chronic axotomy model, FK506 doubled the number of regenerated motoneurons identified by retrograde labeling and increased the number of myelinated axons in the distal nerve stump, whereas after chronic denervation, FK506 did not improve the reduced capacity of SCs to support axonal regeneration. These results demonstrate that FK506 not only increases the rate of axonal regeneration, but also promotes regeneration of neurons whose regenerative capacity is significantly reduced by chronic axotomy. Taken together, the data shows that FK506 acts directly on the neuron to accelerate and promote axonal regeneration consistent with in vitro observations.
Supported by MRC, Canada; Fujisawa, Japan
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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