Neuroscience 2001 Abstract
| Presentation Number: | 716.9 |
|---|---|
| Abstract Title: | ENDOCANNABINOID MECHANISMS OF STRESS-INDUCED ANALGESIA. |
| Authors: |
Hohmann, A. G.*1
; Neely, M. H.1
; Suplita, R. L.1
; Nackley, A. G.1
; Holmes, P. V.1
; Crystal, J. D.1
1Dept Psych, Univ Georgia, Athens, GA |
| Primary Theme and Topics |
Sensory Systems - Pain Modulation -- Opiods, cannabinoids and other peptides and receptors |
| Session: |
716. Pain modulation: cannabinoids and receptors Poster |
| Presentation Time: | Wednesday, November 14, 2001 8:00 AM-9:00 AM |
| Location: | Exhibit Hall G-9 |
| Keywords: | anandamide, pain, cannabinoids, opioid |
Environmental stressors activate an endogenous mechanism for suppressing pain that is insensitive to opioid antagonists. The mechanism underlying nonopioid stress-induced analgesia has remained a major gap in the knowledge base. The present studies were conducted to test the hypothesis that nonopioid stress-induced analgesia is mediated by a cannabinoid mechanism. Nonopioid stress-induced analgesia was induced in rats using brief, continuous footshock. SR141716A, a competitive antagonist for cannabinoid CB1 receptors, blocked nonopioid stress-induced analgesia, defined behaviorally in the tail-flick test. By contrast, the opioid antagonist naltrexone and the competitive antagonist for cannabinoid CB2 receptors, SR144528, failed to alter stress analgesia in this paradigm. Blocking reuptake of the endocannabinoid anandamide with AM404 potentiated nonopioid stress-induced analgesia. Acute administration of the prototypic classical cannabinoid delta9-tetrahydrocannabinol similarly enhanced stress analgesia. By contrast, rats rendered tolerant to cannabinoids showed reductions in stress analgesia relative to vehicle treatment. These data are consistent with direct support for the hypothesis that environmental stressors release endocannabinoids, as demonstrated by high performance liquid chromatography mass spectrometry (HPLC/MS). The present data demonstrate that nonopioid stress-induced analgesia proceeds through a CB1 mechanism and is mediated by endogenous cannabinoids.
Supported by DA13149 and UGARF
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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