Neuroscience 2004 Abstract
| Presentation Number: | 643.3 |
|---|---|
| Abstract Title: | High-resolution anatomical & functional MRI of somatosensory cortex in squirrel monkeys at 9.4T. |
| Authors: |
Nelson, A. J.*1
; Cheney, C. A.1
; Chen, I.2
; Napadow, V.2
; Dai, G.2
; Moore, C. I.1
1McGovern Inst. for Brain Res., Massachusetts Inst. of Technol., Cambridge, MA 2MA, E25-414, 02139, |
| Primary Theme and Topics |
Sensory Systems - Tactile/Somatosensory -- Cortex imaging |
| Secondary Theme and Topics | Sensory Systems<br />- Tactile/Somatosensory<br />-- Cortex and thalamocortical relationships |
| Session: |
643. Cortex Imaging II Poster |
| Presentation Time: | Tuesday, October 26, 2004 10:00 AM-11:00 AM |
| Location: | San Diego Convention Center - Hall A-H, Board # W28 |
| Keywords: | fMRI, tactile, vibrotactile |
We investigated somatosensory cortical activation in squirrel monkeys using high-field imaging (9.4T, Bruker) during vibrotactile and electrocutaneous stimulation of the hand. Accompanying high-resolution T1 anatomical experiments were used to define the laminar organization of SI. Vibrotactile stimulation was administered by piezoelectric elements that drove a circular contact (0.5 mm dia.) onto the surface of a digit segment. Electrocutaneous stimuli were presented via electrodes positioned on the digit volar surfaces and base of the palm. All stimuli were delivered in a blocked design. In T1-images, whole brain coverage was achieved with a 7 cm coil to achieve a 195µm in-plane resolution. For EPI data, a 3 cm coil was positioned over somatosensory cortex for a 625µm in-plane resolution. Isoflurane anesthesia (0.5-0.8%) was maintained by monitoring physiological variables (SpO2, BPM, CO2; see Cheney et al., this meeting). Data was acquired from two monkeys that were scanned over 20 fMRI sessions. Preliminary analysis of anatomical data revealed consistent differences in cortical thickness and lamination pattern between putative areas 4 & 3b. Both stimuli evoked robust and repeatable fMRI activation in the putative SI hand area (see figure) and also in the lateral sulcus. Our findings suggest that vibrotactile stimuli are well suited for investigating somatosensory cortex at high-field strengths.
Supported by McGovern Institute for Brain Research; Martinos Center
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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