Neuroscience 2003 Abstract
| Presentation Number: | 622.7 |
|---|---|
| Abstract Title: | Antiemetic effects of ondansetron and delta-9-tetrahydrocannabinol in <I>Suncus murinus</I> (house MuSK shrew). |
| Authors: |
Kwiatkowska, M.*1
; Parker, L. A.2
1Dept. Psychology, Wilfrid Laurier Univ, Waterloo, Canada 2ON, 75 Univ Ave West, N2L 3C5, |
| Primary Theme and Topics |
Cognition and Behavior - Animal Cognition and Behavior -- Emotional learning & memory systems and modulation of memory |
| Session: |
622. Animal Cognition and Behavior: Learning I Poster |
| Presentation Time: | Tuesday, November 11, 2003 10:00 AM-11:00 AM |
| Location: | Morial Convention Center - Hall F-I, Board # V11 |
| Keywords: | CANNABINOIDS, SEROTONIN, SHREW, EMESIS |
The present study investigated the potential of various doses of delta-9-tetrahydrocannabinol (THC), Ondansetron
(5-HT3 receptor antagonist, OND) and a combined pretreatment of OND and THC to suppress cisplatin-induced emesis in the Suncus murinus. OND and THC both dose-dependently suppressed cisplatin-induced vomiting and retching. Furthermore, a combined pretreatment of doses of the two drugs that were ineffective alone (0.02 mg/kg OND and 1.25 mg/kg THC) completely suppressed vomiting and retching. This suggests that a combination of lower doses of these agents may be an effective alternative treatment for vomiting that may have fewer side effects than higher doses of either agent alone.
(5-HT3 receptor antagonist, OND) and a combined pretreatment of OND and THC to suppress cisplatin-induced emesis in the Suncus murinus. OND and THC both dose-dependently suppressed cisplatin-induced vomiting and retching. Furthermore, a combined pretreatment of doses of the two drugs that were ineffective alone (0.02 mg/kg OND and 1.25 mg/kg THC) completely suppressed vomiting and retching. This suggests that a combination of lower doses of these agents may be an effective alternative treatment for vomiting that may have fewer side effects than higher doses of either agent alone.
Supported by CIHR
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
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