Neuroscience 2005 Abstract
| Presentation Number: | 644.18 |
|---|---|
| Abstract Title: | The effects of tetrahydrocannabinol or methylphenidate pretreatment on rat’s behavior in spatial accuracy task. |
| Authors: |
Novikov, N. I.*1
; Kubie, J. L.2
; Dow-Edwards, D.1
1Physiology/Pharmacology, SUNY Downstate Med. Ctr., Brooklyn, NY 2NY, SUNY Hlth Sci.CtrBox 29, 11203, |
| Primary Theme and Topics |
Cognition and Behavior - Animal Cognition and Behavior -- Attention |
| Secondary Theme and Topics | Disorders of the Nervous System<br />- Addiction and Drugs of Abuse<br />-- Cannabinoids |
| Session: |
644. Attention: Pharmacology and Gene Action Poster |
| Presentation Time: | Tuesday, November 15, 2005 9:00 AM-10:00 AM |
| Location: | Washington Convention Center - Hall A-C, Board # GG23 |
| Keywords: | CANNABINOIDS, SPATIAL ORIENTATION, AMPHETAMINE |
Male rats (n = 9) were trained on the accuracy task (Kubie, et al, Abstracts, Society for Neuroscience, 2003), where rat was rewarded when visiting a target location: a 9 cm diameter unmarked circle in a cylindrical enclosure that had 2 cue-cards (black and white) separated by 90 degrees on the walls. Within 5 min sessions, rats must stand still for 1 sec in the target location in order to receive a reward. We examined the effects of tetrahydrocannabinol (THC) or methylphenidate (MPD) pretreatment on this choice response. Drugs were administered ip in increasing doses 1, 3 and 9 mg/kg/day alternating with saline and each rat received either MPD or THC. Different characteristics were registered – the number of correct choices, number of the rewards, speed and number of walking bouts during the session, median distance to choice center and goal, ratio of events in correct and false goals and others. It was found that methylphenidate slightly improved the accuracy of entering the target location since there was a tendency to diminish the mean distance of choices from goal and choice center, though the means were not statistically different. Tetrahydrocannabinol worsened the accuracy by increasing the mean distance from the goal. These data suggest that MPD can improve while THC can impair accuracy in a spatial accuracy task.
Supported by R21MH66852 and R01DAO19348.
Supported by R21MH66852 and R01DAO19348.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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