Neuroscience 2004 Abstract
| Presentation Number: | 623.1 |
|---|---|
| Abstract Title: | Effects of cannabinoids on hippocampal network activity in awake rats. |
| Authors: |
Robbe, D.*1
; Bartho, P.1
; Pare, D.1
; Buzsaki, G.1
1Ctr. for Mol. and Behavioral Neurosci., Rutgers Univ., Newark, NJ |
| Primary Theme and Topics |
Synaptic Transmission and Excitability - Neurotransmitters -- Cannabinoids |
| Secondary Theme and Topics | Cognition and Behavior<br />- Human and Animal Cognition and Behavior<br />-- Learning & memory: Pharmacology |
| Session: |
623. Cannabinoids II Poster |
| Presentation Time: | Tuesday, October 26, 2004 8:00 AM-9:00 AM |
| Location: | San Diego Convention Center - Hall A-H, Board # J11 |
| Keywords: | HIPPOCAMPUS, TETRODE, CANNABINOIDS, RAT |
Marijuana is a widely used drug of abuse and its psychoactive compounds are called cannabinoids. In the brain cannabinoids are known to activate CB1-receptors, and possibly other non-CB1 receptors, which are widely expressed in the neocortex, cerebellum and hippocampus. At the single-cell level, cannabinoids regulate neuronal excitability and decrease release of various neurotransmitters. Moreover, they alter long-term synaptic plasticity, a candidate model of memory storage. At the behavioral level cannabinoids alter memory formation in both laboratory animals and human. Yet, little is known about the link between the effects of cannabinoids at the single-cell level, as studied in slice preparations and their behavioral effects. As a result, the impact of cannabinoids on network activity is poorly understood. We combined silicon and tetrode recordings in the hippocampal CA1 region of freely moving and head-restrained awake rats before and after systemic injection of CP55940, a synthetic cannabinoid. CP55940 decreased the power of the local field potential in a wide range of frequencies (0.1 to 200Hz). These effects were reversed by subsequent injection of SR141716A, a nonselective CB1 antagonist but not by AM251. The mean firing rate of CA1 pyramidal cells was strongly decreased by CP55940 and this effect could be reversed by SR141716A but not AM251. Importantly, the mean firing rate of CA1 interneurons was not affected by CP55940. These findings suggest the involvement of non-CB1 mechanisms in part of the network effects of cannabinoids and indicate differential regulation of principal cell and interneuron activity.
Supported by NIH, Human Frontier Science Program.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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