Neuroscience 2001 Abstract
| Presentation Number: | 685.11 |
|---|---|
| Abstract Title: | In vivo chronic cannabinoid administration impairs spontaneous network activity of cerebellar granule neurons. |
| Authors: |
Ghozland, S.*1
; Espinosa, J. F.2
; Soriano, E.2
; Maldonado, R.1
; Aguado, F.2
1Neuropharmacol, Univ Pompeu Fabra, Barcelona, Spain 2Cell Biol, Univ Barcelona, Barcelona, Spain |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Addiction and Drugs of Abuse -- Opioids and others |
| Session: |
685. Addiction and drugs of abuse: opioids and others III Slide |
| Presentation Time: | Wednesday, November 14, 2001 10:30 AM-10:45 AM |
| Location: | Room 30E |
| Keywords: | CANNABINOIDS, WITHDRAWAL, DRUG ABUSE, FURA-2 |
Acute administration of delta9-tetrahydrocannabinol (THC), the psychoactive ingredient of marihuana, produces dose-dependent locomotor effects that are selectively mediated by activation of CB1 cannabinoid receptors. CB1 receptors are highly expressed in motor control brain regions, such as basal ganglia and cerebellum and modulate synapses between cerebellar granule cells (GC) and Purkinje cells. Chronic THC can induce physical dependence that implicates the cerebellum and THC withdrawal syndrome has an important motor component. However, the neurophysiological adaptive mechanisms occuring during chronic THC treatment and withdrawal remain unexplored.
We aimed to evaluate the effects of chronic THC administration and withdrawal on GC neuronal activity using calcium imaging techniques. We first examined the effects of acute and chronic THC on spontaneous neuronal activity patterns of cerebellar GCs circuits. In order to evaluate the effects of THC withdrawal syndrome on these activity patterns, the selective CB1 cannabinoid receptor antagonist SR141716A was then administered in preparations from mice chronically treated with THC.
Our data provide neurophysiological evidence for the involvement of the cerebellum in the adaptive changes occuring in the CNS during chronic THC treatment and withdrawal. Cerebellar GCs are clearly involved in these processes that lead to the development of cannabinoid physical dependence.
We aimed to evaluate the effects of chronic THC administration and withdrawal on GC neuronal activity using calcium imaging techniques. We first examined the effects of acute and chronic THC on spontaneous neuronal activity patterns of cerebellar GCs circuits. In order to evaluate the effects of THC withdrawal syndrome on these activity patterns, the selective CB1 cannabinoid receptor antagonist SR141716A was then administered in preparations from mice chronically treated with THC.
Our data provide neurophysiological evidence for the involvement of the cerebellum in the adaptive changes occuring in the CNS during chronic THC treatment and withdrawal. Cerebellar GCs are clearly involved in these processes that lead to the development of cannabinoid physical dependence.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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