Neuroscience 2001 Abstract
| Presentation Number: | 685.10 |
|---|---|
| Abstract Title: | FUNCTIONAL CONSEQUENCES OF THE REPEATED ADMINISTRATION OF Δ<sup>9</sup>-TETRAHYDROCANNABINOL. |
| Authors: |
Whitlow, C. T.*1
; Freedland, C. S.1
; Porrino, L. J.1
1Dept of Physiology & Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Addiction and Drugs of Abuse -- Opioids and others |
| Secondary Theme and Topics | Autonomic, Limbic and Other Systems<br />- Brain Metabolism, Transport and Blood Flow |
| Session: |
685. Addiction and drugs of abuse: opioids and others III Slide |
| Presentation Time: | Wednesday, November 14, 2001 10:15 AM-10:30 AM |
| Location: | Room 30E |
| Keywords: | deoxyglucose, cannabinoid, limbic system, tolerance |
The chronic administration of Δ9-tetrahydrocannabinol (Δ9-THC) produces tolerance to its behavioral effects, and such tolerance can be associated with changes in cannabinoid receptor number as well as function. The purpose of the present study was to identify patterns of functional activity that accompany chronic Δ9-THC administration utilizing quantitative 2-[14C]deoxyglucose autoradiography (2DG). Male Sprague-Dawley rats were treated with Δ 9-THC (10 mg/kg, i.p.) or vehicle for either one or 21 days. Metabolic mapping with the 2DG method was applied 15 minutes after the final drug treatment. The single administration of Δ9-THC produced a global effect, significantly depressing rates of glucose utilization in 35 of 39 brain structures measured. In contrast, the administration of Δ9-THC, following repeated exposure, did not significantly alter rates of glucose utilization in the majority of structures analyzed. These data demonstrate that tolerance develops to the cerebral metabolic effects of Δ9-THC following chronic administration. Glucose utilization, however, remained depressed in a subset of regions including prefrontal cortex, nucleus accumbens, caudate, basolateral amygdala, anterior cingulate cortex, mediodorsal thalamus, and median raphe. That functional activity remains depressed primarily in limbic structures, known to be involved in the processing of motivational and emotional information, suggests that the behaviors subserved by these structures may be differentially affected by chronic Δ9-THC exposure.
Supported by Supported by DA05911 (CTW), DA05940 (CSF), DA06634 (LJP).
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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