Neuroscience 2005 Abstract
| Presentation Number: | 49.2 |
|---|---|
| Abstract Title: | The antianalgesia induced by dextro-morphine or levo-morphine against levo-morphine-produced antinociception is mediated by glial stimulation in the mouse spinal cord. |
| Authors: |
Schwasinger, E. T.*1
; Wu, H.1
; Thompson, J.1
; Sun, H.1
; Terashvili, M.1
; Tseng, L. F.1
1Anesthesiology, Med. Col. of Wisconsin, Milwaukee, WI |
| Primary Theme and Topics |
Sensory and Motor Systems - Pain -- Spinal cord processing: Pharmacology |
| Session: |
49. Opioid Modulation and Tolerance Poster |
| Presentation Time: | Saturday, November 12, 2005 2:00 PM-3:00 PM |
| Location: | Washington Convention Center - Hall A-C, Board # Q4 |
| Keywords: | analgesia, glia, opioid, spinal cord |
The antianalgesia induced by dextro-morphine or levo-morphine against levo-morphine-produced antinociception is mediated by glial stimulation in the mouse spinal cord E.T. Schwasinger, H.-E. Wu, J. Thompson, H.-S. Sun, M. Terashvili and L.F. Tseng1. 1Dept. of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226.
We have previously demonstrated that the naturally occurring levo-morphine at a sub-analgesic picromolar dose or synthetic stereo-enantiomer dextro-morphine at a femtomolar dose pretreated intrathecally (i.t.) induces antianalgesia against levo-morphine-produced antinociception (Wu et al, JPET 310:240, 2004; Wu et al., SFN, 2005). Present study was then undertaken to determine if the antianalgesia induced by dextro-morphine or levo-morphine against levo-morphine-produced antinociception is mediated by the glial stimulation. The effect of the glial inhibitor propentofylline on the attenuation of the levo-morphine-produced tail-flick (TF) inhibition induced by dextro-morphine or levo-morphine pretreatment were then studied in male CD-1 mice. Intrathecal (i.t.) pretreatment with dextro-morphine (33 fmol) or levo-morphine (0.3 nmol) for 45 min attenuated the i.t. morphine-produced TF inhibition. The attenuation of morphine-produced TF inhibition induced by dextro-morphine or levo-morphine pretreatment was reversed dose-dependently by i.t. co-administration with propentofylline (3.3-98 nmol). It is concluded that the dextro-morphine- and levo-morphine-induced antianalgesia against levo-morphine-produced antinociception are mediated by a non-opioidergic glial pathway (Supported by NIH Grant DA 12588).
We have previously demonstrated that the naturally occurring levo-morphine at a sub-analgesic picromolar dose or synthetic stereo-enantiomer dextro-morphine at a femtomolar dose pretreated intrathecally (i.t.) induces antianalgesia against levo-morphine-produced antinociception (Wu et al, JPET 310:240, 2004; Wu et al., SFN, 2005). Present study was then undertaken to determine if the antianalgesia induced by dextro-morphine or levo-morphine against levo-morphine-produced antinociception is mediated by the glial stimulation. The effect of the glial inhibitor propentofylline on the attenuation of the levo-morphine-produced tail-flick (TF) inhibition induced by dextro-morphine or levo-morphine pretreatment were then studied in male CD-1 mice. Intrathecal (i.t.) pretreatment with dextro-morphine (33 fmol) or levo-morphine (0.3 nmol) for 45 min attenuated the i.t. morphine-produced TF inhibition. The attenuation of morphine-produced TF inhibition induced by dextro-morphine or levo-morphine pretreatment was reversed dose-dependently by i.t. co-administration with propentofylline (3.3-98 nmol). It is concluded that the dextro-morphine- and levo-morphine-induced antianalgesia against levo-morphine-produced antinociception are mediated by a non-opioidergic glial pathway (Supported by NIH Grant DA 12588).
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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